Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells
Jazyk angličtina Země Francie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20381639
DOI
10.1016/j.micinf.2010.03.015
PII: S1286-4579(10)00088-2
Knihovny.cz E-zdroje
- MeSH
- dendritické buňky virologie MeSH
- interleukin-6 metabolismus MeSH
- klíště virologie MeSH
- kultivované buňky MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- sliny fyziologie MeSH
- TNF-alfa metabolismus MeSH
- viry klíšťové encefalitidy patogenita MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- interleukin-6 MeSH
- TNF-alfa MeSH
Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.
Citace poskytuje Crossref.org
History of Arbovirus Research in the Czech Republic
Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells
Modulation of host immunity by tick saliva
