Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells
Language English Country France Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20381639
DOI
10.1016/j.micinf.2010.03.015
PII: S1286-4579(10)00088-2
Knihovny.cz E-resources
- MeSH
- Dendritic Cells virology MeSH
- Interleukin-6 metabolism MeSH
- Ixodes virology MeSH
- Cells, Cultured MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Saliva physiology MeSH
- Tumor Necrosis Factor-alpha metabolism MeSH
- Encephalitis Viruses, Tick-Borne pathogenicity MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Interleukin-6 MeSH
- Tumor Necrosis Factor-alpha MeSH
Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.
References provided by Crossref.org
History of Arbovirus Research in the Czech Republic
Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells
Modulation of host immunity by tick saliva
