- Klíčová slova
- imunopatogeneze,
- MeSH
- dendritické buňky imunologie MeSH
- lidé MeSH
- mikrobiota MeSH
- nemoci úst etiologie imunologie klasifikace patofyziologie patologie MeSH
- parodontitida etiologie imunologie patofyziologie MeSH
- Sjögrenův syndrom etiologie imunologie patofyziologie patologie MeSH
- sliny fyziologie MeSH
- stomatitida * imunologie klasifikace patofyziologie MeSH
- ústa * fyziologie imunologie patofyziologie patologie MeSH
- zubní kaz etiologie imunologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
To evaluate parallel circadian rhythms in salivary and serum cortisol concentrations during 48-h period, sampling was performed in six clinically healthy dogs of various breeds housed under natural photoperiod in spring (sunrise 05:20, sunset 20:20). Saliva and blood samples were taken every 3 h for a 48-h period to determine the daily changes in salivary and serum cortisol concentrations. The relationship between salivary and serum cortisol level was determined as well. In the two-day period of monitoring, salivary and serum cortisol concentrations showed the same trend. Their levels started to increase at sunrise and reached their peak in the middle of the photophase. Both parameters showed a high robustness of rhythm. A positive correlation between salivary and serum cortisol concentration was observed during the day 1 and 2. Acrophase and robustness of rhythm showed no statistically significant difference between salivary and serum cortisol concentrations. We can claim that salivary cortisol, a measure of free cortisol, follows the circadian rhythm of serum cortisol. Therefore, saliva sampling is a valid and non-invasive technique useful in chronomedicine to estimate free cortisol.
- MeSH
- cirkadiánní rytmus * fyziologie MeSH
- hydrokortison * analýza fyziologie krev MeSH
- psi fyziologie krev MeSH
- sérum fyziologie MeSH
- sliny fyziologie MeSH
- statistika jako téma MeSH
- zvířata MeSH
- Check Tag
- psi fyziologie krev MeSH
- zvířata MeSH
- Publikační typ
- srovnávací studie MeSH
- Klíčová slova
- slina, vylučování sliny,
- MeSH
- lidé MeSH
- sliny fyziologie mikrobiologie sekrece účinky léků MeSH
- xerostomie * diagnóza etiologie patofyziologie prevence a kontrola radioterapie terapie MeSH
- Check Tag
- lidé MeSH
Sdělení se zabývá problematikou xerostomie, která může být projevem dysfunkce slinných žláz, vedlejšího účinku léčiv nebo celkového onemocnění. Příspěvek shrnuje základní diagnostické, terapeutické a preventivní přístupy u onemocnění, která způsobují suchost v ústech.
Xerostomia can be a result of salivary gland dysfunction, adverse effect of drugs, or systemic disease. Review of literature as well as diagnostic, preventive and therapy approaches of dry mouth syndrome are discussed in the review.
Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.
- MeSH
- dendritické buňky virologie MeSH
- interleukin-6 metabolismus MeSH
- klíště virologie MeSH
- kultivované buňky MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- sliny fyziologie MeSH
- TNF-alfa metabolismus MeSH
- viry klíšťové encefalitidy patogenita MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- dítě MeSH
- fluoridy terapeutické užití MeSH
- fyziologie výživy dětí MeSH
- fyziologie výživy kojenců MeSH
- kojenec MeSH
- lidé MeSH
- matky výchova MeSH
- mezioborová komunikace MeSH
- orální hygiena normy MeSH
- rodinní lékaři MeSH
- sladidla klasifikace škodlivé účinky MeSH
- sliny fyziologie mikrobiologie MeSH
- stomatologie MeSH
- ústa mikrobiologie MeSH
- zubní kaz etiologie mikrobiologie prevence a kontrola MeSH
- zubní plak mikrobiologie MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- MeSH
- diagnostické techniky a postupy MeSH
- diagnóza stomatologická MeSH
- dítě MeSH
- Lactobacillus acidophilus MeSH
- lidé MeSH
- mikrobiologické jevy MeSH
- náchylnost k zubnímu kazu MeSH
- novorozenec MeSH
- sliny fyziologie mikrobiologie MeSH
- Streptococcus mutans patogenita MeSH
- ústa mikrobiologie MeSH
- zubní kaz diagnóza mikrobiologie prevence a kontrola MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- novorozenec MeSH
This is a review of current knowledge on the use of saliva, gingival cervical fluid and mucosal transudate in the detection of some oral and systemic diseases as well as drugs. Oral fluid is a diagnostic medium that can be easily collected and with minimal invasion but it has been neglected in the past. Today, saliva is being used more often to diagnose: HIV virus, oro-facial and systemic tumors, cardiovascular disease and in detecting addictive substances. Neutropil levels in saliva may also indicate successful bone marrow transplant. Oral fluid is now systematically being researched and oral fluid analysis is being compared with the analysis of other diagnostic media such as blood and urine. A number of recent studies have focused on oncogenic marker detection and its monitoring in saliva. The latest clinical and laboratory findings on diagnostic markers of oropharyngeal carcinoma in oral fluid could be the beginning of their wider use as a diagnostic medium. Oral fluid can also be also used to diagnose other malignancies such as breast cancer which was one of the first malignant tumors to be detected using genetic protein biomarkers. Raised levels of CA15-3 and the epidermal growth factor (EGF) receptor have been found in patients with breast cancer and elevated levels of CA 125 and the glycoprotein complex in the saliva of ovarian cancer patients. CONCLUSION: Doubtless, the diagnostic value of saliva, aided by current technological development will increase rapidly in the near future.
