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Involvement of envelope-glycoprotein glycans in HIV-1 biology and infection
M. Raska, J. Novak
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, přehledy
NLK
ProQuest Central
od 2006-02-01 do 2018-12-31
Medline Complete (EBSCOhost)
od 2006-01-01
Health & Medicine (ProQuest)
od 2006-02-01 do 2018-12-31
- MeSH
- antigenní variace MeSH
- HIV infekce imunologie terapie virologie MeSH
- HIV-1 patogenita fyziologie MeSH
- lidé MeSH
- neutralizující protilátky MeSH
- polysacharidy imunologie metabolismus MeSH
- přichycení viru MeSH
- proteiny virového obalu imunologie metabolismus MeSH
- vakcíny proti AIDS MeSH
- virulence MeSH
- vysoce aktivní antiretrovirová terapie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
Infection of host cells with HIV-1 depends on a highly glycosylated virus envelope glycoprotein (Env) and host-cell receptors. Glycans participate substantially in Env folding and in the binding of virions to the host-cell surface and indirectly affect cellular uptake of HIV-1. Moreover, Env glycans could protect HIV-1 from host's neutralizing antibodies, but some glycans, on the other hand, represent targets for neutralizing antibodies. Variability of Env and its glycans in the HIV-1 strains from around the world as well as in patients during disease progression contributes substantially to further HIV-1 spreading in spite of the progress in basic HIV-1 research, vaccine development, and highly active antiretroviral therapy of HIV-1 infections.
Citace poskytuje Crossref.org
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