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N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity
E. Petrlíková, K. Waisser, V. Buchta, P. Jílek, M. Vejsová,
Bioorganic & medicinal chemistry letters.
2010 ;
20 (15) :
4535-8.
[pub] 20100611
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc12026304
- MeSH
- Antifungal Agents chemistry pharmacology MeSH
- Fluconazole pharmacology MeSH
- Quantitative Structure-Activity Relationship MeSH
- Microbial Sensitivity Tests MeSH
- Thioamides chemistry pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The in vitro biological activity of N-benzylsalicylthioamides was evaluated against eight fungal strains by the broth microdilution method and the results were compared with those obtained with fluconazole. The compounds exhibited an in vitro antifungal activity against the fluconazole-susceptible as well as the fluconazole-resistant fungal strains. The biological activity was analyzed by quantitative structure-activity relationship (QSAR).
References provided by Crossref.org
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