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Preparation and properties of new co-crystals of ibandronate with gluco- or galactopyranoside derivatives

Z. Oktabec, J. Kos, Z. Mandelova, L. Havelkova, T. Pekarek, A. Rezacova, L. Placek, M. Tkadlecova, J. Havlicek, J. Dohnal, J. Jampílek

. 2010 ; 15 (12) : 8973-8987. [pub] 20101208

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc12026596

Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically controlled crystallization processes. Seventy-seven prepared samples were analyzed by means of FT-NIR, FT-Raman spectrometry and solid state NMR spectroscopy. New entities of ibandronate monosodium salt with phenyl-β-D-galactopyranoside were found and characterized. The absorption of these potential new co-crystals was investigated by means of PAMPA experiments. In the present study the relationships between the chemical structures of the studied compounds required for co-crystal generation are discussed.

Citace poskytuje Crossref.org

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