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Lung transplantation in cystic fibrosis patients in the Czech Republic: initial single-center experience
L.V. Bartáková, L. Fila, S. Adámek, J. Pozniak, M. Malý, J. Burkert, J. Šimonek, R. Lischke
Language English Country United States
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Burkholderia cepacia complex isolation & purification MeSH
- Time Factors MeSH
- Cystic Fibrosis microbiology mortality surgery MeSH
- Child MeSH
- Adult MeSH
- Risk Assessment MeSH
- Burkholderia Infections microbiology MeSH
- Kaplan-Meier Estimate MeSH
- Humans MeSH
- Survival Rate MeSH
- Adolescent MeSH
- Young Adult MeSH
- Risk Factors MeSH
- Waiting Lists mortality MeSH
- Lung Transplantation adverse effects mortality MeSH
- Treatment Outcome MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic MeSH
BACKGROUND: Lung transplantation is a well established treatment for advanced lung diseases. METHODS: We compared the clinical results of patients with cystic fibrosis (CF) entered into the waiting list with those of patients after lung transplantation. RESULTS: Among 36 patients with CF on the waiting list, 23 underwent lung transplantation, 8 died, 3 are still on the waiting list, and 2 were excluded from the waiting list. The median waiting list time of 0.48 years (range, 0.03-2.37) was insignificantly longer for patients who died compared with transplanted patients (0.97 vs 0.44 years). Mortality of waiting-list patients was 25.8%. The median survival of transplant patients of 7.48 years (range 0.00-10.85 years) was significantly lower among patients who were colonized (BCC) versus those who were not Burkholderia cepacia complex (0.19 vs 7.48 years; P = .041). The 1-, 3-, and 5-year patient survivals after lung transplantation were 72.9, 54.4, and 54.4, respectively. CONCLUSION: The results of patients with cystic fibrosis on the waiting list versus after lung transplantation in our center were similar to those reported in the literature. We confirmed a less favorable prognosis of BCC-colonized patients.
3 chirurgická klinika 1 LF UK FN Motol Praha
3 chirurgická klinika 1 LFUK a FNM Praha
Department of Cardiology University Hospital Motol 1st Medical Faculty Prague Czech Republic
Department of Pulmonology 2nd Medical School of Charles University Prague Czech Republic
Transplantation Center University Hospital Motol Prague Czech Republic
References provided by Crossref.org
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- $a BACKGROUND: Lung transplantation is a well established treatment for advanced lung diseases. METHODS: We compared the clinical results of patients with cystic fibrosis (CF) entered into the waiting list with those of patients after lung transplantation. RESULTS: Among 36 patients with CF on the waiting list, 23 underwent lung transplantation, 8 died, 3 are still on the waiting list, and 2 were excluded from the waiting list. The median waiting list time of 0.48 years (range, 0.03-2.37) was insignificantly longer for patients who died compared with transplanted patients (0.97 vs 0.44 years). Mortality of waiting-list patients was 25.8%. The median survival of transplant patients of 7.48 years (range 0.00-10.85 years) was significantly lower among patients who were colonized (BCC) versus those who were not Burkholderia cepacia complex (0.19 vs 7.48 years; P = .041). The 1-, 3-, and 5-year patient survivals after lung transplantation were 72.9, 54.4, and 54.4, respectively. CONCLUSION: The results of patients with cystic fibrosis on the waiting list versus after lung transplantation in our center were similar to those reported in the literature. We confirmed a less favorable prognosis of BCC-colonized patients.
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