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The initial bearing capacities of subchondral bone replacements considerably contributing to chondrogenesis

M. Petrtýl, J. Danešová, J. Lísal, L. Senolt, H. Hulejová, M. Polanská, Z. Bastl, Z. Kruliš, P. Cerný

. 2010 ; 12 (3) : 59-65.

Language English Country Poland

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12027117

The degeneration of articular cartilage results from osteoarthritis and many other forms of severe arthritis. Current treatments for cartilage repair are less than satisfactory, and rarely restore a full function or return the tissue to its natural state. The leading strategies in the treatment are aimed at the transplantation of cells and/or the use of various biological grafts, bioactive agents, or biologically compatible implant matrices. The insertion of a crushed autologous bone graft has been reported as a possible therapy. However, the regenerative quality of the tissue was less than 70% of healthy cartilage for fragments and controls. The implantation of cycloolefin-blend 3D-cylinders with hydrogel scaffolds on their proximal parts and with the applications of type I collagen films is one of several surgical therapies. The replacement and continuous biomechanical properties of the subchondral bone play an important role in the morphology and the quality of chondrogenesis. The initial biomechanical stability of COC-blend polymer replacements in the subchondral bone contributes to the formation of a new cartilage tissue. The initial bearing capacities of the implanted tissue/replacements and vertical positions of the replacements have a principal influence upon both the quality and the quantity of new articular cartilage.

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$a The degeneration of articular cartilage results from osteoarthritis and many other forms of severe arthritis. Current treatments for cartilage repair are less than satisfactory, and rarely restore a full function or return the tissue to its natural state. The leading strategies in the treatment are aimed at the transplantation of cells and/or the use of various biological grafts, bioactive agents, or biologically compatible implant matrices. The insertion of a crushed autologous bone graft has been reported as a possible therapy. However, the regenerative quality of the tissue was less than 70% of healthy cartilage for fragments and controls. The implantation of cycloolefin-blend 3D-cylinders with hydrogel scaffolds on their proximal parts and with the applications of type I collagen films is one of several surgical therapies. The replacement and continuous biomechanical properties of the subchondral bone play an important role in the morphology and the quality of chondrogenesis. The initial biomechanical stability of COC-blend polymer replacements in the subchondral bone contributes to the formation of a new cartilage tissue. The initial bearing capacities of the implanted tissue/replacements and vertical positions of the replacements have a principal influence upon both the quality and the quantity of new articular cartilage.
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$a Danešová, Jana
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$a Šenolt, Ladislav, $d 1976- $7 xx0056558 $u Institute of Rheumatology, Department of Experimental and Clinical Rheumatology, First Faculty of Medicine, Charles University, Na Slupi 4, 12850 Prague 2, Czech Republic. seno@revma.cz
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$a Hulejová, Hana $7 xx0077461 $u Institute of Rheumatology, Department of Experimental Rheumatology, Na Slupi 4, 128 50 Prague 2, Czech Republic. hule@revma.cz
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