-
Something wrong with this record ?
Activated CD8+ T cells contribute to clearance of gastric Cryptosporidium muris infections
M. Kváč, A. Kodádková, B. Sak, D. Květoňová, M. Jalovecká, M. Rost, J. Salát
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1997 to 1 year ago
Medline Complete (EBSCOhost)
from 1998-01-01 to 1 year ago
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
Wiley Free Content
from 1997 to 1 year ago
- MeSH
- CD4-Positive T-Lymphocytes immunology MeSH
- CD8-Positive T-Lymphocytes immunology MeSH
- Cryptosporidium immunology MeSH
- Cryptosporidiosis immunology MeSH
- Mice, SCID MeSH
- Mice MeSH
- Adoptive Transfer MeSH
- Stomach immunology parasitology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of both naive and immune CD4+ T lymphocyte subpopulations protects SCID mice against cryptosporidiosis. Moreover, a significant biological impact of activated CD8+ T cells against gastric cryptosporidiosis was observed. The significant difference in the course and intensity of the infection in reconstituted SCID mice was found to be dependent on the protective function of both the CD4+ and CD8+ T-cell populations transferred. While SCID mice reconstituted with either immune or naive CD4+ or immune CD8+ T-cell subpopulations resolved the infection within 29, 37 and 51 days post-infection, respectively, those reconstituted with naive CD8+ T cells suffered from chronic infection similar to control SCID mice. Reconstitution with CD4+ T cells resulted in suppression of oocyst excretion and shortening of patent period in comparison with SCID mice reconstituted with CD8+ T cells. Thus, although CD4+ T cells are considered important in protective immunity, our results are the first to demonstrate the involvement of activated CD8+ T lymphocytes in the protection of mice against gastric cryptosporidiosis.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12027157
- 003
- CZ-PrNML
- 005
- 20160428101422.0
- 007
- ta
- 008
- 120816s2011 enk f 000 0#eng||
- 009
- AR
- 024 7_
- $a 10.1111/j.1365-3024.2010.01271.x $2 doi
- 035 __
- $a (PubMed)21204850
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Kváč, Martin $u Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská, České Budějovice, Czech Republic; Faculty of Agriculture, University of South Bohemia in České Budějovice, Studentská, České Budějovice, Czech Republic $7 jcu2010587967
- 245 10
- $a Activated CD8+ T cells contribute to clearance of gastric Cryptosporidium muris infections / $c M. Kváč, A. Kodádková, B. Sak, D. Květoňová, M. Jalovecká, M. Rost, J. Salát
- 520 9_
- $a The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of both naive and immune CD4+ T lymphocyte subpopulations protects SCID mice against cryptosporidiosis. Moreover, a significant biological impact of activated CD8+ T cells against gastric cryptosporidiosis was observed. The significant difference in the course and intensity of the infection in reconstituted SCID mice was found to be dependent on the protective function of both the CD4+ and CD8+ T-cell populations transferred. While SCID mice reconstituted with either immune or naive CD4+ or immune CD8+ T-cell subpopulations resolved the infection within 29, 37 and 51 days post-infection, respectively, those reconstituted with naive CD8+ T cells suffered from chronic infection similar to control SCID mice. Reconstitution with CD4+ T cells resulted in suppression of oocyst excretion and shortening of patent period in comparison with SCID mice reconstituted with CD8+ T cells. Thus, although CD4+ T cells are considered important in protective immunity, our results are the first to demonstrate the involvement of activated CD8+ T lymphocytes in the protection of mice against gastric cryptosporidiosis.
- 650 _2
- $a převzatá imunita $7 D019264
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a CD4-pozitivní T-lymfocyty $x imunologie $7 D015496
- 650 _2
- $a CD8-pozitivní T-lymfocyty $x imunologie $7 D018414
- 650 _2
- $a kryptosporidióza $x imunologie $7 D003457
- 650 _2
- $a Cryptosporidium $x imunologie $7 D003458
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a myši SCID $7 D016513
- 650 _2
- $a žaludek $x imunologie $x parazitologie $7 D013270
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Kodádková, Alena $7 _AN071116 $u Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská, České Budějovice, Czech Republic
- 700 1_
- $a Sak, Bohumil $7 xx0043634 $u Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská, České Budějovice, Czech Republic
- 700 1_
- $a Květoňová, Dana $7 xx0130605 $u Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská, České Budějovice, Czech Republic
- 700 1_
- $a Jalovecká, Marie, $d 1987- $7 xx0060826 $u Faculty of Science, University of South Bohemia in České Budějovice, Branišovská, České Budějovice, Czech Republic
- 700 1_
- $a Rost, M. $u Faculty of Economics, University of South Bohemia in České Budějovice, Studentská, České Budějovice, Czech Republic
- 700 1_
- $a Salát, Jiří $7 xx0105109 $u Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia in České Budějovice, Branišovská, České Budějovice, Czech Republic
- 773 0_
- $w MED00003687 $t Parasite immunology $x 1365-3024 $g Roč. 33, č. 4 (2011), s. 210-216
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/21204850 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y m $z 0
- 990 __
- $a 20120816 $b ABA008
- 991 __
- $a 20160428101148 $b ABA008
- 999 __
- $a ok $b bmc $g 949199 $s 784503
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2011 $b 33 $c 4 $d 210-216 $i 1365-3024 $m Parasite immunology $n Parasite Immunol $x MED00003687
- LZP __
- $b NLK112 $a Pubmed-20120816/11/02
