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Magnetic resonance imaging of stem cell migration
E. Syková, P. Jendelová, V. Herynek,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- barvení a značení metody MeSH
- buněčná diferenciace MeSH
- buněčný tracking metody MeSH
- dextrany chemie MeSH
- ferrokyanidy analýza MeSH
- kontrastní látky chemie MeSH
- krysa rodu rattus MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- magnetické nanočástice chemie MeSH
- magnetismus metody MeSH
- mezenchymální kmenové buňky cytologie metabolismus MeSH
- myši MeSH
- pohyb buněk MeSH
- transplantace mezenchymálních kmenových buněk MeSH
- viabilita buněk MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Noninvasive cellular imaging allows the real-time tracking of grafted cells as well as the monitoring of their migration. In this review, we will focus on cell tracking using MRI, since MRI is noninvasive, clinically transferable, and displays good resolution, ranging from 50 μm in animal experiments up to 300 μm using whole body clinical scanners. In addition to information about grafted cells, MRI provides information about the surrounding tissue (i.e., lesion size, edema, inflammation), which may negatively affect graft survival or the functional recovery of the tissue. Transplanted cells are labeled with MR contrast agents in vitro prior to transplantation in order to visualize them in the host tissue. The chapter will focus on the use of superparamagnetic iron oxide nanoparticles (SPIO), because they have strong effects on T2 relaxation yet do not affect cell viability, and will provide an overview of different modifications of SPIO and their use in MR tracking in living organisms.
Citace poskytuje Crossref.org
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