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Intracellular cytokine production in peripheral blood lymphocytes: a comparison of values in infertile and fertile women
P. Horká, R. Jarošová, K. Malíčková, I. Janatková, H. Marečková, T. Zima, M. Kalousová,
Language English Country Denmark
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Medline Complete (EBSCOhost)
from 2002-08-01 to 1 year ago
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
- MeSH
- Cytokines biosynthesis blood MeSH
- Adult MeSH
- Fertility immunology MeSH
- Interferon-gamma biosynthesis blood MeSH
- Interleukin-2 biosynthesis blood MeSH
- Interleukin-4 biosynthesis blood MeSH
- Humans MeSH
- Flow Cytometry MeSH
- T-Lymphocytes, Helper-Inducer immunology metabolism MeSH
- Pregnancy immunology MeSH
- Tumor Necrosis Factor-alpha biosynthesis blood MeSH
- Infertility, Female immunology physiopathology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy immunology MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
PROBLEM: To analyze the relation of the fertility and pregnancy of women of childbearing age to the intracellular (IC) production of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and interleukins 2 and 4 (IL-2 and IL-4). METHOD OF STUDY: Intracellular cytokine production in peripheral blood CD3(+) CD4(+) lymphocytes was analyzed by flow cytometry in 185 women being treated for infertility and 50 fertile women of childbearing age. RESULTS: Infertile women have a significantly higher IC production of TNF-α, IFN-γ, IL-2, and IL-4 and higher ratios of TNF-α/IL-2, TNF-α/IL-4, and TNF-α/IFN-γ compared to the fertile women. CONCLUSION: Cytokines produced by Th lymphocytes are important in orchestrating the immune response during conception, and Th-cell dysregulation could be a reason for infertility.
References provided by Crossref.org
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- $a PROBLEM: To analyze the relation of the fertility and pregnancy of women of childbearing age to the intracellular (IC) production of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and interleukins 2 and 4 (IL-2 and IL-4). METHOD OF STUDY: Intracellular cytokine production in peripheral blood CD3(+) CD4(+) lymphocytes was analyzed by flow cytometry in 185 women being treated for infertility and 50 fertile women of childbearing age. RESULTS: Infertile women have a significantly higher IC production of TNF-α, IFN-γ, IL-2, and IL-4 and higher ratios of TNF-α/IL-2, TNF-α/IL-4, and TNF-α/IFN-γ compared to the fertile women. CONCLUSION: Cytokines produced by Th lymphocytes are important in orchestrating the immune response during conception, and Th-cell dysregulation could be a reason for infertility.
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