Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Alteration of the cardiac sympathetic innervation is modulated by duration of diabetes in female rats

J. Švíglerová, J. Mudra, Z. Tonar, J. Slavíková, J. Kuncová,

. 2011 ; 2011 () : 835932. [pub] 20110717

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12028151

To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years. Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration. Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores. Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12028151
003      
CZ-PrNML
005      
20121207102248.0
007      
ta
008      
120817e20110717xxu f 000 0#eng||
009      
AR
024    7_
$a 10.1155/2011/835932 $2 doi
035    __
$a (PubMed)21792353
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Švíglerová, Jitka $u Department of Physiology, Faculty of Medicine in Plzeň, Charles University, Lidická 1, 301 00 Plzeň, Czech Republic.
245    10
$a Alteration of the cardiac sympathetic innervation is modulated by duration of diabetes in female rats / $c J. Švíglerová, J. Mudra, Z. Tonar, J. Slavíková, J. Kuncová,
520    9_
$a To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years. Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration. Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores. Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one.
650    _2
$a zvířata $7 D000818
650    _2
$a atropin $x farmakologie $7 D001285
650    _2
$a experimentální diabetes mellitus $x chemicky indukované $x metabolismus $x patofyziologie $7 D003921
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a srdce $x účinky léků $x inervace $x patofyziologie $7 D006321
650    _2
$a srdeční frekvence $x účinky léků $x fyziologie $7 D006339
650    _2
$a lidé $7 D006801
650    _2
$a inzulin $x metabolismus $7 D007328
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a metipranolol $x farmakologie $7 D014290
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Wistar $7 D017208
650    _2
$a pohlavní dimorfismus $7 D012727
650    _2
$a streptozocin $7 D013311
650    _2
$a sympatický nervový systém $x účinky léků $x patologie $x patofyziologie $7 D013564
650    _2
$a sympatolytika $x farmakologie $7 D013565
650    _2
$a časové faktory $7 D013997
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Mudra, Jiří
700    1_
$a Tonar, Zbyněk
700    1_
$a Slavíková, Jana
700    1_
$a Kuncová, Jitka
773    0_
$w MED00165258 $t Experimental diabetes research $x 1687-5303 $g Roč. 2011(20110717), s. 835932
856    41
$u https://pubmed.ncbi.nlm.nih.gov/21792353 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m
990    __
$a 20120817 $b ABA008
991    __
$a 20121207102322 $b ABA008
999    __
$a ok $b bmc $g 950193 $s 785497
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2011 $b 2011 $d 835932 $e 20110717 $i 1687-5303 $m Experimental Diabetes Research $n Exp Diabetes Res $x MED00165258
LZP    __
$a Pubmed-20120817/11/04

Najít záznam

Citační ukazatele

Možnosti archivace