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Alteration of the cardiac sympathetic innervation is modulated by duration of diabetes in female rats
J. Švíglerová, J. Mudra, Z. Tonar, J. Slavíková, J. Kuncová,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 2007
PubMed Central
from 2007 to 2012
Europe PubMed Central
from 2007 to 2012
Open Access Digital Library
from 2007-04-05 to 2012-12-31
Open Access Digital Library
from 2007-01-01 to 2012-12-31
Open Access Digital Library
from 2007-01-01
Medline Complete (EBSCOhost)
from 2007-01-01 to 2012-01-31
PubMed
21792353
DOI
10.1155/2011/835932
Knihovny.cz E-resources
- MeSH
- Atropine pharmacology MeSH
- Time Factors MeSH
- Diabetes Mellitus, Experimental chemically induced metabolism physiopathology MeSH
- Insulin metabolism MeSH
- Rats MeSH
- Humans MeSH
- Metipranolol pharmacology MeSH
- Sex Characteristics MeSH
- Rats, Wistar MeSH
- Heart drug effects innervation physiopathology MeSH
- Heart Rate drug effects physiology MeSH
- Streptozocin MeSH
- Sympathetic Nervous System drug effects pathology physiopathology MeSH
- Sympatholytics pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years. Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration. Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores. Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one.
References provided by Crossref.org
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