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Heterogeneity of DNA ploidy in endometrial carcinoma: comparison of different tissue samples obtained during diagnosis and treatment

Libalova P., Vernerova Z., Hubickova-Heringova L., Pinterova D., Kolostova K., Bobek V., Tikovsky K., Housa D., Kubecova M., Pecen L., Svoboda B.

. 2012 ; 26 (3) : 473-480.

Jazyk angličtina Země Řecko

Typ dokumentu srovnávací studie, časopisecké články, Research Support, U.S. Gov't, Non-P.H.S.

Perzistentní odkaz   https://www.medvik.cz/link/bmc12034562

Grantová podpora
NS9975 MZ0 CEP - Centrální evidence projektů

AIM: Comparison of DNA ploidy status of different tumour tissue samples (fresh/frozen vs. paraffin-embedded; curettage vs. hysterectomy samples) obtained during diagnosis and treatment of patients with endometrial carcinoma. PATIENTS AND METHODS: DNA ploidy status and conventional prognostic parameters were recorded for 74 patients with endometrial carcinoma prospectively. RESULTS: In 59 (79.7%) patients the DNA status was described as diploid in all analyzed tissue samples. The remaining 15 (20.3%) cases were described as DNA aneuploid in at least one of the corresponding tissue samples. The concordance between DNA ploidy status in fresh vs. paraffin-embedded hysterectomy samples as well as curettage vs. hysterectomy paraffin-embedded samples was high (kappa coefficient κ=0.6348, 95% confidence interval CI=0.3673-0.9023, and p=0.6408, 95% CI=0.3977-0.8838), however, the methods are not interchangeable. CONCLUSION: The DNA ploidy discordance observed in our study group seems to document intratumoral heterogeneity that should be expected when applying DNA ploidy status in the clinical management of endometrial carcinoma.

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$a Líbalová, Pavla $7 xx0135162 $u Department of Gynaecology and Obstetrics, Third Faculty of Medicine of Charles University and The Kralovske Vinohrady University Hospital, Prague, Czech Republic. pavla.libalova@lf3.cuni.cz
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$a Heterogeneity of DNA ploidy in endometrial carcinoma: comparison of different tissue samples obtained during diagnosis and treatment / $c Libalova P., Vernerova Z., Hubickova-Heringova L., Pinterova D., Kolostova K., Bobek V., Tikovsky K., Housa D., Kubecova M., Pecen L., Svoboda B.
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$a AIM: Comparison of DNA ploidy status of different tumour tissue samples (fresh/frozen vs. paraffin-embedded; curettage vs. hysterectomy samples) obtained during diagnosis and treatment of patients with endometrial carcinoma. PATIENTS AND METHODS: DNA ploidy status and conventional prognostic parameters were recorded for 74 patients with endometrial carcinoma prospectively. RESULTS: In 59 (79.7%) patients the DNA status was described as diploid in all analyzed tissue samples. The remaining 15 (20.3%) cases were described as DNA aneuploid in at least one of the corresponding tissue samples. The concordance between DNA ploidy status in fresh vs. paraffin-embedded hysterectomy samples as well as curettage vs. hysterectomy paraffin-embedded samples was high (kappa coefficient κ=0.6348, 95% confidence interval CI=0.3673-0.9023, and p=0.6408, 95% CI=0.3977-0.8838), however, the methods are not interchangeable. CONCLUSION: The DNA ploidy discordance observed in our study group seems to document intratumoral heterogeneity that should be expected when applying DNA ploidy status in the clinical management of endometrial carcinoma.
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$a Vernerová, Zdenka, $d 1960-2020 $7 jo2002104672 $u Department of Pathology, Third Faculty of Medicine of Charles University and The Kralovske Vinohrady University Hospital, Prague, Czech Republic
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$a Hubičková-Heringová, Lucie $7 xx0074015 $u Department of Histology and Embryology, Third Faculty of Medicine of Charles University and The Kralovske Vinohrady University Hospital, Prague, Czech Republic
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$a Pintérová, Daniela $7 xx0102048 $u Department of Tumour Biology, Third Faculty of Medicine of Charles University and The Kralovske Vinohrady University Hospital, Prague, Czech Republic
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$a Bobek, Vladimír $7 xx0162734 $u Department of Tumour Biology, Third Faculty of Medicine of Charles University and The Kralovske Vinohrady University Hospital, Prague, Czech Republic; Department of Surgery, Third Faculty of Medicine of Charles University and The Kralovske Vinohrady University Hospital, Prague, Czech Republic
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$a Housa, Daniel, $d 1975- $7 xx0076895 $u Department of Pathology, Glangwili Hospital, Carmarthen, Dyfed, United Kingdom
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$a Kubecová, Martina $7 xx0083618 $u Department of Oncology, Third Faculty of Medicine of Charles University and The Kralovske Vinohrady University Hospital, Prague, Czech Republic
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$a Pecen, Ladislav $7 xx0102807 $u SIRO Clinpharm, Prague, Czech Republic
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