-
Something wrong with this record ?
Anxiogenic effect of low-dose methamphetamine in the test of elevated plus-maze
Pometlová M., Nohejlová-Deykun K., Šlamberová R.
Language English Country Czech Republic
NLK
Directory of Open Access Journals
from 2012
Medline Complete (EBSCOhost)
from 2012-01-01
- MeSH
- Anti-Anxiety Agents pharmacology MeSH
- Maze Learning drug effects MeSH
- Behavior, Animal drug effects MeSH
- Rats MeSH
- Methamphetamine pharmacology MeSH
- Rats, Wistar MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
Methamphetamines (MA) are psychostimulant drugs that are known to change individuals' behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans. In animal experiments, the test of elevated plus-maze (EPM) is widely used. This test is appropriate for evaluation of anxiolytic and anxiogenic drug effects, or for examination of specific subtypes of anxiety disorders. The aim of the present study was to examine the effect of acute single dose of MA (1 mg/kg) on the behavior of laboratory rat in the EPM. The detailed ethologic analysis of behavior was performed using a modified protocol based on the study of Fernández Espejo (1997). Our results demonstrated that MA affects rat's behavior in the EPM in the majority of analyzed categories. The present protocol allowed us to determine positive anxiogenic effect of MA.
References provided by Crossref.org
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12036425
- 003
- CZ-PrNML
- 005
- 20130123105933.0
- 007
- ta
- 008
- 121113s2012 xr d f 000 0eng||
- 009
- AR
- 024 7_
- $a 10.14712/23362936.2015.20 $2 doi
- 035 __
- $a (PubMed)22980563
- 040 __
- $a ABA008 $d ABA008 $e AACR2 $b cze
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Pometlová, Marie, $d 1960- $7 xx0102924 $u Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
- 245 10
- $a Anxiogenic effect of low-dose methamphetamine in the test of elevated plus-maze / $c Pometlová M., Nohejlová-Deykun K., Šlamberová R.
- 504 __
- $a Literatura $b 25
- 520 9_
- $a Methamphetamines (MA) are psychostimulant drugs that are known to change individuals' behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans. In animal experiments, the test of elevated plus-maze (EPM) is widely used. This test is appropriate for evaluation of anxiolytic and anxiogenic drug effects, or for examination of specific subtypes of anxiety disorders. The aim of the present study was to examine the effect of acute single dose of MA (1 mg/kg) on the behavior of laboratory rat in the EPM. The detailed ethologic analysis of behavior was performed using a modified protocol based on the study of Fernández Espejo (1997). Our results demonstrated that MA affects rat's behavior in the EPM in the majority of analyzed categories. The present protocol allowed us to determine positive anxiogenic effect of MA.
- 650 02
- $a zvířata $7 D000818
- 650 02
- $a anxiolytika $x farmakologie $7 D014151
- 650 02
- $a chování zvířat $x účinky léků $7 D001522
- 650 02
- $a mužské pohlaví $7 D008297
- 650 02
- $a bludiště - učení $x účinky léků $7 D018782
- 650 02
- $a methamfetamin $x farmakologie $7 D008694
- 650 02
- $a krysa rodu Rattus $7 D051381
- 650 02
- $a potkani Wistar $7 D017208
- 700 1_
- $a Nohejlová, Kateryna. $7 mzk2013788463 $u Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
- 700 1_
- $a Šlamberová, Romana $7 xx0052834 $u Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
- 773 0_
- $t Prague medical report $x 1214-6994 $g Roč. 113, č. 3 (2012), s. 223-230 $w MED00013414
- 856 41
- $u https://pmr.lf1.cuni.cz/media/pdf/pmr_2012113030223.pdf $y plný text volně přístupný
- 910 __
- $a ABA008 $b A 7 $c 1071 $y 3
- 990 __
- $a 20121112084558 $b ABA008
- 991 __
- $a 20130123110052 $b ABA008
- 999 __
- $a ok $b bmc $g 958373 $s 793954
- BAS __
- $a 3
- BMC __
- $a 2012 $b 113 $c 3 $d 223-230 $i 1214-6994 $m Prague Medical Report $n Prague Med. Rep. $x MED00013414
- LZP __
- $a NLK 2012-47/vtme
