Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice

R. Matej, T. Olejar, O. Janouskova, K. Holada,

. 2012 ; 93 (Pt 9) : 2057-61.

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc13000733

Proteinase-activated receptor 2 (PAR2) has recently been identified to be a possible modulator of neurodegeneration. To investigate whether PAR2 plays a role in prion infection, we inoculated PAR2-deficient (PAR2(-/-)) and wild-type (WT) mice intracerebrally with the Rocky Mountain Laboratory strain of scrapie. PAR2(-/-) mice demonstrated a delayed onset of clinical symptoms, including weight loss, and demonstrated moderate but highly significant prolongation of survival over WT controls. Concomitantly, no apparent differences in brain pathology, infectivity or features of brain prion protein between deceased WT and PAR2(-/-) mice were found. Our study suggests that PAR2 deletion modulates dynamics of the disease without gross perturbation of its pathogenesis.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13000733
003      
CZ-PrNML
005      
20130111102520.0
007      
ta
008      
130108s2012 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1099/vir.0.043877-0 $2 doi
035    __
$a (PubMed)22694901
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Matej, Radoslav $u Department of Pathology and Molecular Medicine, Thomayer Teaching Hospital, Videnska 800, Prague 4, 140 59, Czech Republic.
245    10
$a Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice / $c R. Matej, T. Olejar, O. Janouskova, K. Holada,
520    9_
$a Proteinase-activated receptor 2 (PAR2) has recently been identified to be a possible modulator of neurodegeneration. To investigate whether PAR2 plays a role in prion infection, we inoculated PAR2-deficient (PAR2(-/-)) and wild-type (WT) mice intracerebrally with the Rocky Mountain Laboratory strain of scrapie. PAR2(-/-) mice demonstrated a delayed onset of clinical symptoms, including weight loss, and demonstrated moderate but highly significant prolongation of survival over WT controls. Concomitantly, no apparent differences in brain pathology, infectivity or features of brain prion protein between deceased WT and PAR2(-/-) mice were found. Our study suggests that PAR2 deletion modulates dynamics of the disease without gross perturbation of its pathogenesis.
650    _2
$a zvířata $7 D000818
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a delece genu $7 D017353
650    _2
$a lidé $7 D006801
650    _2
$a myši $7 D051379
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a myši knockoutované $7 D018345
650    _2
$a priony $x genetika $x metabolismus $7 D011328
650    _2
$a receptor PAR-2 $x nedostatek $x genetika $7 D044464
650    _2
$a scrapie $x enzymologie $x genetika $x metabolismus $x mortalita $7 D012608
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Olejar, Tomas
700    1_
$a Janouskova, Olga
700    1_
$a Holada, Karel
773    0_
$w MED00002692 $t The Journal of general virology $x 1465-2099 $g Roč. 93, č. Pt 9 (2012), s. 2057-61
856    41
$u https://pubmed.ncbi.nlm.nih.gov/22694901 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20130108 $b ABA008
991    __
$a 20130111102627 $b ABA008
999    __
$a ok $b bmc $g 963515 $s 798897
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 93 $c Pt 9 $d 2057-61 $i 1465-2099 $m Journal of general virology $n J Gen Virol $x MED00002692
LZP    __
$a Pubmed-20130108

Najít záznam

Citační ukazatele

Možnosti archivace