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Visfatin is secreted into the breast milk and is correlated with weight changes of the infant after the birth
J. Bienertová-Vašků, P. Bienert, F. Zlámal, J. Tomandl, M. Tomandlová, Z. Dostálová, A. Vašků,
Jazyk angličtina Země Irsko
Typ dokumentu časopisecké články, práce podpořená grantem
Odkazy
PubMed
21741723
DOI
10.1016/j.diabres.2011.06.009
Knihovny.cz E-zdroje
- MeSH
- analýza rozptylu MeSH
- bílá tuková tkáň účinky léků metabolismus MeSH
- časové faktory MeSH
- dospělí MeSH
- hmotnostní přírůstek účinky léků fyziologie MeSH
- index tělesné hmotnosti MeSH
- kojenec MeSH
- lidé MeSH
- longitudinální studie MeSH
- mateřské mléko účinky léků metabolismus MeSH
- nikotinamidfosforibosyltransferasa metabolismus sekrece MeSH
- novorozenec MeSH
- porodní hmotnost účinky léků fyziologie MeSH
- průzkumy a dotazníky MeSH
- těhotenství MeSH
- Check Tag
- dospělí MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
INTRODUCTION: Visfatin is a recently identified adipokine with numerous metabolic and immunoregulatory properties that has been implicated in the regulation of the white adipose tissue (WAT) and significant changes in visfatin levels were reported during pregnancy. The aim of the study was to investigate dynamics of visfatin levels in maternal serum and human breast milk during a 180-d period after the delivery. MATERIALS AND METHODS: : Breast milk and venous blood samples were obtained from 24 healthy lactating women with uncomplicated, physiological pregnancy and appropriate-for-gestational age neonates and serum-milk sample duos were collected at the time of birth, at the 1-3, 12-14, 28-30, 88-90 and 178-180 postpartum. RESULTS: Our study demonstrates that (1) visfatin is abundantly secreted into breast milk in humans, reaching approx. 100× higher concentrations compared to maternal serum; (2) visfatin concentrations in maternal serum show significant variations after the delivery and (3) visfatin concentration in colostrum could be used for prediction of the subsequent weight development (less/more severe weight loss during first 3 days after the birth) of the infant. DISCUSSION: Our data suggest that visfatin could play an important role in regulation of adiposity of the infant after the birth.
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- $a INTRODUCTION: Visfatin is a recently identified adipokine with numerous metabolic and immunoregulatory properties that has been implicated in the regulation of the white adipose tissue (WAT) and significant changes in visfatin levels were reported during pregnancy. The aim of the study was to investigate dynamics of visfatin levels in maternal serum and human breast milk during a 180-d period after the delivery. MATERIALS AND METHODS: : Breast milk and venous blood samples were obtained from 24 healthy lactating women with uncomplicated, physiological pregnancy and appropriate-for-gestational age neonates and serum-milk sample duos were collected at the time of birth, at the 1-3, 12-14, 28-30, 88-90 and 178-180 postpartum. RESULTS: Our study demonstrates that (1) visfatin is abundantly secreted into breast milk in humans, reaching approx. 100× higher concentrations compared to maternal serum; (2) visfatin concentrations in maternal serum show significant variations after the delivery and (3) visfatin concentration in colostrum could be used for prediction of the subsequent weight development (less/more severe weight loss during first 3 days after the birth) of the infant. DISCUSSION: Our data suggest that visfatin could play an important role in regulation of adiposity of the infant after the birth.
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