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Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome

M Yeganeh, P Henneke, N Rezaei, S Ehl, D Thiel, N Matamoros, C Pietrogrande, T Espanol, J Litzman, JL Franco, O Sanal, SS Kilic, A Breborowicz, A Plebani, E Renner, S Rothenfusser, TR Hawn, C Woellner, B Grimbacher

. 2008 ; 146 (3) : 190-194.

Jazyk angličtina Země Švýcarsko

Typ dokumentu multicentrická studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc13010884

Grantová podpora
NR9192 MZ0 CEP - Centrální evidence projektů

Digitální knihovna NLK
Plný text - Část
Zdroj

E-zdroje Online Plný text

NLK Karger Journals od 1992 do 2009
ProQuest Central od 1998-01-01 do 2015-12-31
Medline Complete (EBSCOhost) od 1998-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 1998-01-01 do 2015-12-31

Odkazy

PubMed 18268386
DOI 10.1159/000115886
Knihovny.cz E-zdroje

Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES. (c) 2008 S. Karger AG, Basel

Citace poskytuje Crossref.org

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