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Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome
M Yeganeh, P Henneke, N Rezaei, S Ehl, D Thiel, N Matamoros, C Pietrogrande, T Espanol, J Litzman, JL Franco, O Sanal, SS Kilic, A Breborowicz, A Plebani, E Renner, S Rothenfusser, TR Hawn, C Woellner, B Grimbacher
Language English Country Switzerland
Document type Multicenter Study, Research Support, Non-U.S. Gov't
Grant support
NR9192
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
Karger Journals
from 1992 to 2009
ProQuest Central
from 1998-01-01 to 2015-12-31
Medline Complete (EBSCOhost)
from 1998-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1998-01-01 to 2015-12-31
PubMed
18268386
DOI
10.1159/000115886
Knihovny.cz E-resources
- MeSH
- Interleukin-8 immunology blood MeSH
- Job Syndrome * immunology MeSH
- Cohort Studies MeSH
- Leukocytes, Mononuclear * immunology MeSH
- Humans MeSH
- Lipopolysaccharides immunology MeSH
- Statistics, Nonparametric MeSH
- Signal Transduction MeSH
- Tumor Necrosis Factor-alpha * immunology MeSH
- Toll-Like Receptor 2 * immunology MeSH
- Toll-Like Receptor 4 * immunology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES. (c) 2008 S. Karger AG, Basel
References provided by Crossref.org
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