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Comparative study of human monocyte and platelet adhesion to hydrogels in vitro - effect of polymer structure
Jirousková M, Bartunková J, Smetana K Jr, Lukás J, Vacík J, Dyr JE
Language English Country United States
Document type Comparative Study
Grant support
IZ1911
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
ProQuest Central
from 1997-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-01-01 to 1 year ago
- MeSH
- Platelet Adhesiveness * MeSH
- Hydrogels * MeSH
- Humans MeSH
- Monocytes * MeSH
- Polymers * MeSH
- In Vitro Techniques MeSH
- Check Tag
- Humans MeSH
- Publication type
- Comparative Study MeSH
Blood platelet and monocyte adhesion was studied in vitro with respect to the influence of hydrophilic polymer chemical functional groups and their charge. The results showed that the strongest adhesion of human monocytes was to coverslips covered with cationic polymer. Platelet adhesion to all tested polymers proved to be negligible; no differences related to the charge of the polymers used were observed. These results show the obvious difference between the biocompatibility and haemocompatibility in vitro which must be taken into consideration during polymer biological properties testing before clinical trials.
References provided by Crossref.org
Literatura
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- $a Jiroušková, Markéta. $7 xx0301857 $u Institute of Hematology and Blood Transfusion, Prague,
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- $a Blood platelet and monocyte adhesion was studied in vitro with respect to the influence of hydrophilic polymer chemical functional groups and their charge. The results showed that the strongest adhesion of human monocytes was to coverslips covered with cationic polymer. Platelet adhesion to all tested polymers proved to be negligible; no differences related to the charge of the polymers used were observed. These results show the obvious difference between the biocompatibility and haemocompatibility in vitro which must be taken into consideration during polymer biological properties testing before clinical trials.
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