Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Peroxisome proliferator-activated receptors in regulation of cytochromes P450: new way to overcome multidrug resistance?

K. Cizkova, A. Konieczna, B. Erdosova, R. Lichnovska, J. Ehrmann,

. 2012 ; 2012 () : 656428.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc13024095

Embryonic and tumour cells are able to protect themselves against various harmful compounds. In human pathology, this phenomenon exists in the form of multidrug resistance (MDR) that significantly deteriorates success of anticancer treatment. Cytochromes P450 (CYPs) play one of the key roles in the xenobiotic metabolism. CYP expression could contribute to resistance of cancer cells to chemotherapy. CYP epoxygenases (CYP2C and CYP2J) metabolize about 20% of clinically important drugs. Besides of drug metabolism, CYP epoxygenases and their metabolites play important role in embryos, normal body function, and tumors. They participate in angiogenesis, mitogenesis, and cell signaling. It was found that CYP epoxygenases are affected by peroxisome proliferator-activated receptor α (PPARα). Based on the results of current studies, we assume that PPARs ligands may regulate CYP2C and CYP2J and in some extent they may contribute to overcoming of MDR in patients with different types of tumours.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13024095
003      
CZ-PrNML
005      
20130710095719.0
007      
ta
008      
130703s2012 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2012/656428 $2 doi
035    __
$a (PubMed)23193364
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Cizkova, Katerina $u Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic. keri@email.cz
245    10
$a Peroxisome proliferator-activated receptors in regulation of cytochromes P450: new way to overcome multidrug resistance? / $c K. Cizkova, A. Konieczna, B. Erdosova, R. Lichnovska, J. Ehrmann,
520    9_
$a Embryonic and tumour cells are able to protect themselves against various harmful compounds. In human pathology, this phenomenon exists in the form of multidrug resistance (MDR) that significantly deteriorates success of anticancer treatment. Cytochromes P450 (CYPs) play one of the key roles in the xenobiotic metabolism. CYP expression could contribute to resistance of cancer cells to chemotherapy. CYP epoxygenases (CYP2C and CYP2J) metabolize about 20% of clinically important drugs. Besides of drug metabolism, CYP epoxygenases and their metabolites play important role in embryos, normal body function, and tumors. They participate in angiogenesis, mitogenesis, and cell signaling. It was found that CYP epoxygenases are affected by peroxisome proliferator-activated receptor α (PPARα). Based on the results of current studies, we assume that PPARs ligands may regulate CYP2C and CYP2J and in some extent they may contribute to overcoming of MDR in patients with different types of tumours.
650    _2
$a zvířata $7 D000818
650    _2
$a systém (enzymů) cytochromů P-450 $x metabolismus $7 D003577
650    12
$a mnohočetná léková rezistence $7 D018432
650    12
$a chemorezistence $7 D019008
650    _2
$a lidé $7 D006801
650    _2
$a biologické modely $7 D008954
650    _2
$a receptory aktivované proliferátory peroxizomů $x metabolismus $7 D047492
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Konieczna, Anna $u -
700    1_
$a Erdosova, Bela $u -
700    1_
$a Lichnovska, Radka $u -
700    1_
$a Ehrmann, Jiri $u -
773    0_
$w MED00008233 $t Journal of biomedicine & biotechnology $x 1110-7251 $g Roč. 2012(2012), s. 656428
856    41
$u https://pubmed.ncbi.nlm.nih.gov/23193364 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20130703 $b ABA008
991    __
$a 20130710100142 $b ABA008
999    __
$a ok $b bmc $g 987775 $s 822475
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 2012 $d 656428 $i 1110-7251 $m Journal of biomedicine and biotechnology $n J Biomed Biotechnol $x MED00008233
LZP    __
$a Pubmed-20130703

Najít záznam

Citační ukazatele

Možnosti archivace