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Efficient iron uptake via a reductive mechanism in procyclic Trypanosoma brucei
J. Mach, J. Tachezy, R. Sutak,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
ProQuest Central
od 2000-12-01 do 2023-12-31
Medline Complete (EBSCOhost)
od 2007-06-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 2000-12-01 do 2023-12-31
Public Health Database (ProQuest)
od 2000-12-01 do 2023-12-31
PubMed
22924933
DOI
10.1645/ge-3237.1
Knihovny.cz E-zdroje
- MeSH
- elektroforéza v polyakrylamidovém gelu MeSH
- FMN-reduktasa metabolismus MeSH
- interakce hostitele a parazita MeSH
- mitochondrie metabolismus MeSH
- oxidace-redukce MeSH
- Trypanosoma brucei brucei metabolismus MeSH
- železité sloučeniny metabolismus MeSH
- železnaté sloučeniny metabolismus MeSH
- železo metabolismus MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The bloodstream form of Trypanosoma brucei acquires iron from transferrin by receptor-mediated endocytosis. However, it is unknown how procyclic forms that cannot bind transferrin acquire iron. Here, we show that the procyclic form of T. brucei efficiently takes up iron from ferric complexes via a reductive mechanism and that iron obtained using this mechanism is transported to, and used in, the mitochondria. The affinity of the transport system is comparable to that of Saccharomyces cerevisiae , with an apparent K(m) of 0.85 μM.
Citace poskytuje Crossref.org
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