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Some biological actions of PEG-conjugated RNase A oligomers

P Pouckova, J Skvor, G Gotte, F Vottariello, JT Slavik, J Matousek, DV Laurents, M Libonati, J Soucek

. 2006 ; 53 (1) : 79-85.

Jazyk angličtina Země Slovensko

Typ dokumentu práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc13029615

Grantová podpora
NR8233 MZ0 CEP - Centrální evidence projektů

Previously we have shown that monomeric RNase A has no significant biological activity, whereas its oligomers (dimer to tetramer) prepared by lyophilizing from 50% acetic acid solutions, show remarkable aspermatogenic and antitumor activities. Furthermore, conjugates prepared by chemical binding of native RNase A to polyethylene glycol (PEG) have shown a significant aspermatogenic and antitumor activities. In this work we show that the chemical conjugation of PEG to the RNase A C-dimer, and to the two RNase A trimers (NC-trimer and C- trimer) decreases the aspermatogenic activity of the oligomers while increasing their inhibitory activity on the growth of the human UB900518 amelanotic melanoma transplanted in athymic nude mice. Moreover, the PEG-conjugated RNaseA oligomers are devoid, like the free oligomers, of any embryotoxic activity.

Bibliografie atd.

Literatura

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