-
Je něco špatně v tomto záznamu ?
The coiled coil motif in polymer drug delivery systems
M. Pechar, R. Pola,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- MeSH
- aminokyselinové motivy * MeSH
- hydrogely MeSH
- konformace proteinů MeSH
- lékové transportní systémy metody MeSH
- molekulární modely MeSH
- rekombinantní proteiny aplikace a dávkování genetika farmakologie MeSH
- rozpustnost MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
The coiled coil is a superhelical structural protein motif that has been thoroughly investigated in recent years. Because of the relatively well-understood principles that determine the properties of coiled coil peptides and proteins, macromolecular systems containing the coiled coil motif have been suggested for various applications. This short review focuses on hybrid polymer coiled coil systems designed for drug delivery purposes. After a short introduction, the most important features of the coiled coils (stability, association number, oligomerization selectivity and orientation of helices) are described, and the factors influencing these characteristics are discussed. Several examples of the most interesting biomedical applications of the polymer-coiled coil systems (according to the authors' opinion) are presented.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc13031941
- 003
- CZ-PrNML
- 005
- 20131002114426.0
- 007
- ta
- 008
- 131002s2012 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.biotechadv.2012.01.003 $2 doi
- 035 __
- $a (PubMed)22266376
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Pechar, Michal $u Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic. pechar@imc.cas.cz
- 245 14
- $a The coiled coil motif in polymer drug delivery systems / $c M. Pechar, R. Pola,
- 520 9_
- $a The coiled coil is a superhelical structural protein motif that has been thoroughly investigated in recent years. Because of the relatively well-understood principles that determine the properties of coiled coil peptides and proteins, macromolecular systems containing the coiled coil motif have been suggested for various applications. This short review focuses on hybrid polymer coiled coil systems designed for drug delivery purposes. After a short introduction, the most important features of the coiled coils (stability, association number, oligomerization selectivity and orientation of helices) are described, and the factors influencing these characteristics are discussed. Several examples of the most interesting biomedical applications of the polymer-coiled coil systems (according to the authors' opinion) are presented.
- 650 12
- $a aminokyselinové motivy $7 D020816
- 650 _2
- $a lékové transportní systémy $x metody $7 D016503
- 650 _2
- $a hydrogely $7 D020100
- 650 _2
- $a molekulární modely $7 D008958
- 650 _2
- $a konformace proteinů $7 D011487
- 650 _2
- $a rekombinantní proteiny $x aplikace a dávkování $x genetika $x farmakologie $7 D011994
- 650 _2
- $a rozpustnost $7 D012995
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Pola, Robert $u -
- 773 0_
- $w MED00000793 $t Biotechnology advances $x 1873-1899 $g Roč. 31, č. 1 (2012), s. 90-6
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/22266376 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20131002 $b ABA008
- 991 __
- $a 20131002114943 $b ABA008
- 999 __
- $a ok $b bmc $g 996028 $s 830386
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2012 $b 31 $c 1 $d 90-6 $i 1873-1899 $m Biotechnology advances $n Biotechnol Adv $x MED00000793
- LZP __
- $a Pubmed-20131002
