-
Je něco špatně v tomto záznamu ?
Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury
E Sykova, A Homola, R Mazanec, H Lachmann, SL Konradova, P Kobylka, R Padr, J Neuwirth, V Komrska, V Vavra, J Stulik, M Bojar
Jazyk angličtina Země Spojené státy americké
Typ dokumentu práce podpořená grantem
Grantová podpora
NR8339
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
Odkazy
PubMed
17269439
DOI
10.3727/000000006783464381
Knihovny.cz E-zdroje
- MeSH
- akutní nemoc MeSH
- autologní transplantace MeSH
- chronická nemoc MeSH
- dospělí MeSH
- elektrofyziologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- následné studie MeSH
- obnova funkce fyziologie MeSH
- poranění míchy chirurgie patofyziologie patologie MeSH
- regenerace nervu fyziologie MeSH
- transplantace kostní dřeně * metody MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
Stem cell transplants into spinal cord lesions may help to improve regeneration and spinal cord function. Clinical studies are necessary for transferring preclinical findings from animal experiments to humans. We investigated the transplantation of unmanipulated autologous bone marrow in patients with transversal spinal cord injury (SCI) with respect to safety, therapeutic time window, implantation strategy, method of administration, and functional improvement. We report data from 20 patients with complete SCI who received transplants 10 to 467 days postinjury. The follow-up examinations were done at 3, 6, and 12 months after implantation by two independent neurologists using standard neurological classification of SCI, including the ASIA protocol, the Frankel score, the recording of motor and somatosensory evoked potentials, and MRI evaluation of lesion size. We compared intra-arterial (via catheterization of a. vertebralis) versus intravenous administration of all mononuclear cells in groups of acute (10-30 days post-SCI, n=7) and chronic patients (2-17 months postinjury, n=13). Improvement in motor and/or sensory functions was observed within 3 months in 5 of 6 patients with intra-arterial application, in 5 of 7 acute, and in 1 of 13 chronic patients. Our case study shows that the implantation of autologous bone marrow cells appears to be safe, as there have been no complications following implantation to date (11 patients followed up for more than 2 years), but longer follow-ups are required to determine that implantation is definitively safe. Also, we cannot yet confirm that the observed beneficial effects were due to the cell therapy. However, the outcomes following transplantation in acute patients, and in one chronic patient who was in stable condition for several months prior to cell implantation, are promising. It is evident that transplantation within a therapeutic window of 3-4 weeks following injury will play an important role in any type of stem cell SCI treatment. Trials involving a larger population of patients and different cell types are needed before further conclusions can be drawn.
Center for Cell Therapy and Tissue Repair Charles University Prague Czech Republic
Department of Spondylosurgery University Hospital Motol Prague Czech Republic
Institute of Experimental Medicine ASCR Prague Czech Republic
Institute of Hematology and Blood Transfusion Prague Czech Republic
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc13033204
- 003
- CZ-PrNML
- 005
- 20131015151249.0
- 007
- ta
- 008
- 131014s2006 xxuda f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3727/000000006783464381 $2 doi
- 035 __
- $a (PubMed)17269439
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Syková, Eva, $d 1944- $7 jn20000710633 $u Center for Cell Therapy and Tissue Repair, Charles University, Prague, Czech Republic; Institute of Experimental Medicine, ASCR, Prague, Czech Republic
- 245 10
- $a Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury / $c E Sykova, A Homola, R Mazanec, H Lachmann, SL Konradova, P Kobylka, R Padr, J Neuwirth, V Komrska, V Vavra, J Stulik, M Bojar
- 504 __
- $a Literatura
- 520 9_
- $a Stem cell transplants into spinal cord lesions may help to improve regeneration and spinal cord function. Clinical studies are necessary for transferring preclinical findings from animal experiments to humans. We investigated the transplantation of unmanipulated autologous bone marrow in patients with transversal spinal cord injury (SCI) with respect to safety, therapeutic time window, implantation strategy, method of administration, and functional improvement. We report data from 20 patients with complete SCI who received transplants 10 to 467 days postinjury. The follow-up examinations were done at 3, 6, and 12 months after implantation by two independent neurologists using standard neurological classification of SCI, including the ASIA protocol, the Frankel score, the recording of motor and somatosensory evoked potentials, and MRI evaluation of lesion size. We compared intra-arterial (via catheterization of a. vertebralis) versus intravenous administration of all mononuclear cells in groups of acute (10-30 days post-SCI, n=7) and chronic patients (2-17 months postinjury, n=13). Improvement in motor and/or sensory functions was observed within 3 months in 5 of 6 patients with intra-arterial application, in 5 of 7 acute, and in 1 of 13 chronic patients. Our case study shows that the implantation of autologous bone marrow cells appears to be safe, as there have been no complications following implantation to date (11 patients followed up for more than 2 years), but longer follow-ups are required to determine that implantation is definitively safe. Also, we cannot yet confirm that the observed beneficial effects were due to the cell therapy. However, the outcomes following transplantation in acute patients, and in one chronic patient who was in stable condition for several months prior to cell implantation, are promising. It is evident that transplantation within a therapeutic window of 3-4 weeks following injury will play an important role in any type of stem cell SCI treatment. Trials involving a larger population of patients and different cell types are needed before further conclusions can be drawn.
- 590 __
- $a bohemika - dle Pubmed
- 650 02
- $a akutní nemoc $7 D000208
- 650 02
- $a dospělí $7 D000328
- 650 12
- $a transplantace kostní dřeně $x metody $7 D016026
- 650 02
- $a chronická nemoc $7 D002908
- 650 02
- $a elektrofyziologie $7 D004594
- 650 02
- $a ženské pohlaví $7 D005260
- 650 02
- $a následné studie $7 D005500
- 650 02
- $a lidé $7 D006801
- 650 02
- $a magnetická rezonanční tomografie $7 D008279
- 650 02
- $a mužské pohlaví $7 D008297
- 650 02
- $a regenerace nervu $x fyziologie $7 D009416
- 650 02
- $a obnova funkce $x fyziologie $7 D020127
- 650 02
- $a poranění míchy $x chirurgie $x patofyziologie $x patologie $7 D013119
- 650 02
- $a autologní transplantace $7 D014182
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Homola, Aleš $7 xx0278724 $u Center for Cell Therapy and Tissue Repair, Charles University, Prague, Czech Republic; Institute of Experimental Medicine, ASCR, Prague, Czech Republic
- 700 1_
- $a Mazanec, Radim, $d 1959- $7 xx0037204 $u Department of Neurology, University Hospital Motol and 2nd Medical Faculty, Charles University, Prague, Czech Republic
- 700 1_
- $a Lachmann, Hynek $7 xx0214026 $u Department of Neurology, University Hospital Motol and 2nd Medical Faculty, Charles University, Prague, Czech Republic
- 700 1_
- $a Langkramer, Šimona $7 _AN029289 $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic
- 700 1_
- $a Kobylka, Petr, $d 1949- $7 xx0060254 $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic
- 700 1_
- $a Pádr, Radek $7 xx0088068 $u Department of Pediatric Hematology and Oncology, University Hospital Motol and 2nd Medical Faculty, Charles University, Prague, Czech Republic
- 700 1_
- $a Neuwirth, Jiří, $d 1960- $7 jn20000620249 $u Department of Pediatric Hematology and Oncology, University Hospital Motol and 2nd Medical Faculty, Charles University, Prague, Czech Republic
- 700 1_
- $a Komrska, Vladimír, $d 1952- $7 xx0081839 $u Department of Imaging Methods, University Hospital Motol and 2nd Medical Faculty, Charles University, Prague, Czech Republic
- 700 1_
- $a Vávra, Vladimír $7 xx0099529 $u Department of Imaging Methods, University Hospital Motol and 2nd Medical Faculty, Charles University, Prague, Czech Republic
- 700 1_
- $a Štulík, Jan, $d 1967- $7 nlk20030127573 $u Department of Spondylosurgery, University Hospital Motol, Prague, Czech Republic
- 700 1_
- $a Bojar, Martin, $d 1947- $7 jn19990009805 $u Department of Neurology, University Hospital Motol and 2nd Medical Faculty, Charles University, Prague, Czech Republic
- 773 0_
- $t Cell Transplantation $x 0963-6897 $g Roč. 15, č. 8-9 (2006), s. 675-687 $p Cell Transplant $w MED00001075
- 773 0_
- $p Cell Transplant $g 15(8-9):675-87, 2006 $x 0963-6897
- 910 __
- $a ABA008 $y 3 $z 0
- 990 __
- $a 20131014151634 $b ABA008
- 991 __
- $a 20131015151831 $b ABA008
- 999 __
- $a ok $b bmc $g 997365 $s 831657
- BAS __
- $a 3
- BMC __
- $a 2006 $b 15 $c 8-9 $d 675-687 $x MED00001075 $i 0963-6897 $m Cell transplantation $n Cell Transplant
- GRA __
- $a NR8339 $p MZ0
- LZP __
- $a 2013-10/gvbo