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14-3-3 proteins: a family of versatile molecular regulators

V. Obsilová, J. Silhan, E. Boura, J. Teisinger, T. Obsil

. 2008 ; 57 (Suppl 3) : S11-S21.
. 2008 ; 57 (Suppl 3) : S11-S21.

Language English Country Czech Republic

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc13034143

The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.

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