Black Crowberry (Empetrum nigrum L.) Flavonoids and Their Health Promoting Activity

. 2016 Dec 07 ; 21 (12) : . [epub] 20161207

Jazyk angličtina Země Švýcarsko Médium electronic

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/pmid27941619

Nowadays, much research attention is focused on underutilized berry crops due to the high antioxidant activity of fruits. Black crowberry (Empetrum nigrum L.) represents an important source of flavonols (quercetin, rutin, myricetin, naringenin, naringin, morin, and kaempferol) and anthocyanins. The fruit components could be utilised as natural colourants or as a part of functional foods and, because of the high antioxidant activity, the berries of black crowberry can be used in the treatment of diseases accompanied with inflammation, or as an effective antibacterial and antifungal remedy. Moreover, the reduction of lipid accumulation and total cholesterol as well as an improvement of postprandial hyperglycaemia have been proven. This review summarizes for the first time the main antioxidants (flavonoids) of black crowberry fruits, with a focus on their health promoting activity.

Zobrazit více v PubMed

Jurikova T., Rop O., Mlcek J., Sochor J., Balla S., Szekeres L., Hegedusova A., Hubalek J., Adam V., Kizek R. Phenolic profile of edible honeysuckle berries (genus Lonicera) and their biological effects. Molecules. 2012;17:61–79. doi: 10.3390/molecules17010061. PubMed DOI PMC

Jurikova T., Sochor J., Rop O., Mlček J., Balla S., Szekes L., Zitný R., Zitka O., Kizek R. Evaluation of polyphenolic profile and nutritional value of non-traditional fruit species in the Czech republic—A comparative study. Molecules. 2012;17:8968–8981. doi: 10.3390/molecules17088968. PubMed DOI PMC

Jurikova T., Balla S., Sochor J., Pohanka M., Mlcek J., Baron M. Flavonoid profile of saskatoon berries (Amelanchier alnifolia Nutt.) and their health promoting effects. Molecules. 2013;18:12571–12586. doi: 10.3390/molecules181012571. PubMed DOI PMC

Skrovankova S., Sumczynski D., Mlcek J., Jurikova T., Sochor J. Bioactive compounds and antioxidant activity in different types of berries. Int. J. Mol. Sci. 2015;16:24673–24706. doi: 10.3390/ijms161024673. PubMed DOI PMC

de la Rosa L.A., Alvarez-Parrilla E., Gonzalez-Aguilar G.A., editors. Fruit and Vegetable Phytochemicals—Chemistry, Nutritional Value and Stability. Willey-Blackwell; Ames, IA, USA: 2010. p. 357.

Halvorsten B.L., Holte K., Myhrstad M.C., Barikno I., Hvattum E., Remberg S.F., Wold A.B., Haffner K., Baugerod H., Andersen L.F., et al. A systematic screening of total antioxidants in dietary plants. J. Nutr. 2002;132:461–471. PubMed

Seeram N.P. Berry fruits: Compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease. J. Agric. Food Chem. 2008;56:627–629. doi: 10.1021/jf071988k. PubMed DOI

Fin C. Empetrum nigrum crowberry. In: Janick J., Paull R.E., editors. The Encyclopedia of Fruits & Nuts. CAB International; Wallingford, Oxfordshire, UK: 2008. p. 348.

Latti A.A., Riihinen K.R., Kainulanien P.S. Analysis of anthocyanin variation in wild populations of bilberry (Vaccinium myrtillus L.) in Finland. J. Agric. Food Chem. 2008;56:190–196. doi: 10.1021/jf072857m. PubMed DOI

Häkkinen S.H., Kärenlampi S.O., Mykkänen H.M., Törrönen A.R. Influence of domestic processing and storage on flavonol contents in berries. J. Agric. Food Chem. 2000;48:2960–2965. doi: 10.1021/jf991274c. PubMed DOI

Laaksonen O., Sandell M., Järvinen R., Kallio H. Orosensory contributing compounds in crowberry (Empetrum nigrum) press-by products. Food Chem. 2011;124:1514–1524. doi: 10.1016/j.foodchem.2010.08.005. DOI

Park S.Y., Lee E.S., Han S.H., Lee H.Y., Lee S. Antioxidative effects of two native berry species, Empetrum nigrum var. japonicum k. Koch and Rubus buergeri miq., from the Jeju island of Korea. J. Food Biochem. 2012;36:675–682. doi: 10.1111/j.1745-4514.2011.00582.x. DOI

Määttä-Riihinen K.R., Kamal-Eldin A., Mattila P.H., González-Paramás A.M., Törrönen A.R. Distribution and contents of phenolic compounds in eighteen scandinavian berry species. J. Agric. Food Chem. 2004;52:4477–4486. doi: 10.1021/jf049595y. PubMed DOI

Ogawa K., Sakakibara H., Iwata R., Ishii T., Sato T., Goda T., Shimoi K., Kumazawa S. Anthocyanin composition and antioxidant activity of the crowberry (Empetrum nigrum) and other berries. J. Agric. Food Chem. 2008;56:4457–4462. doi: 10.1021/jf800406v. PubMed DOI

Linko R., Karppa J., Kallio H., Ahtonen S. Anthocyanin contents of crowberry and crowberry juice. Food Sci. Technol. 1983;16:343–345.

Törrönen R., McDougall G.J., Dobson G., Stewart D., Hellström J., Mattila P., Pihlava J.M., Koskela A., Karjalainen R. Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects. J. Funt. Foods. 2012;4:746–756. doi: 10.1016/j.jff.2012.05.001. DOI

Hyun T.K., Kim H., Ko Y., Kim J. Antioxidant, α-glucosidase inhibitory and anti-inflammatory effects of aerial parts extract from korean crowberry (Empetrum nigrum var. Japonicum) Saudi J. Biol. Sci. 2016;23:181–188. doi: 10.1016/j.sjbs.2015.02.008. PubMed DOI PMC

Lacramioara O., Ciprian M. Antioxidants content in empetrum nigrum fresh and dried fruits. Iran. J. Public Health. 2016;45:263–265. PubMed PMC

Käppä J., Kallio H., Peltonen I., Link R. Anthocyanins of crowberry, Empetrum nigrum coll. J. Food Sci. 1984;49:634–636. doi: 10.1111/j.1365-2621.1984.tb12486.x. DOI

Hakkinen S., Heinonen M., Karenlampi S., Mykkanen H., Ruuskanen J., Torronen R. Screening of selected flavonoids and phenolic acids in 19 berries. Food Res. Int. 1999;32:345–353. doi: 10.1016/S0963-9969(99)00095-2. DOI

Kähkönen M.P., Hopia A.I., Heinonen M. Berry phenolics and their antioxidant activity. J. Agric. Food Chem. 2001;49:4076–4082. doi: 10.1021/jf010152t. PubMed DOI

Dudonne S., Dube P., Anhe F.F., Pilon G., Marette A., Lemire M., Harris C., Dewailly E., Desjardins Y. Comprehensive analysis of phenolic compounds and abscisic acid profiles of twelve native canadian berries. J. Food Compos. Anal. 2015;44:214–224. doi: 10.1016/j.jfca.2015.09.003. DOI

Bakowska-Barczak A.M., Marianchuk M., Kolodziejczyk P. Survey of bioactive components in western Canadian berries. Can. J. Physiol. Pharmacol. 2007;85:1139–1152. doi: 10.1139/Y07-102. PubMed DOI

Vaisanen M., Martz F., Kaarlejarvi E., Julkunen-Tiitto R., Stark S. Phenolic responses of mountain crowberry (Empetrum nigrum ssp. hermaphroditum) to global climate change are compound specific and depend on grazing by reindeer (rangifer tarandus) J. Chem. Ecol. 2013;39:1390–1399. doi: 10.1007/s10886-013-0367-z. PubMed DOI

Kellogg J., Wang J., Flint C., Ribnicky D., Kuhn P., De Mejia E.G., Raskin I., Lila M.A. Alaskan wild berry resources and human health under the cloud of climate change. J. Agric. Food Chem. 2010;58:3884–3900. doi: 10.1021/jf902693r. PubMed DOI PMC

Viljakainen S., Visti A., Laakso S. Concentrations of organic acids and soluble sugars in juices from nordic berries. Acta Agric. Scand. Sect. B Soil Plant Sci. 2002;52:101–109. doi: 10.1080/090647102321089846. DOI

Mlcek J., Jurikova T., Skrovankova S., Sochor J. Quercetin and its anti-allergic immune response. Molecules. 2016;21:623. doi: 10.3390/molecules21050623. PubMed DOI PMC

Nakajima J., Tanaka I., Seo S., Yamazaki M., Saito K. LC/ PDA/ESI-MS profiling and radical scavenging activity of anthocyanins in various berries. J. Biomed. Biotechnol. 2004;2004:241–247. doi: 10.1155/S1110724304404045. PubMed DOI PMC

Heyman L., Axling U., Blanco N., Sterner O., Holm C., Berger K. Evaluation of beneficial metabolic effects of berries in high-fat fed c57bl/6j mice. J. Nutr. Metab. 2014;2014:403041. doi: 10.1155/2014/403041. PubMed DOI PMC

Bae H.S., Kim H.J., Kang J.H., Kudo R., Hosoya T., Kumazawa S., Jun M., Kim O.Y., Ahn M.R. Anthocyanin profile and antioxidant activity of various berries cultivated in Korea. Natl. Prod. Commun. 2015;10:963–968. PubMed

Koskela A.K., Anttonen M.J., Soininen T.H., Saviranta N.M., Auriola S., Julkunen-Tiitto R., Karjalainen R.O. Variation in the anthocyanin concentration of wild populations of crowberries (Empetrum nigrum subsp. hermaphroditum) J. Agric. Food Chem. 2010;58:12286–12291. doi: 10.1021/jf1037695. PubMed DOI

Hellstrom J., Mattila P., Karjalaien R. Stability of anthocyanins in berry juices stored at different temperatures. J. Food Compos. Anal. 2013;31:12–19. doi: 10.1016/j.jfca.2013.02.010. DOI

Koponen J.M., Happonen A.M., Mattila P.H., Törrönen A.R. Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. J. Agric. Food Chem. 2007;55:1612–1619. doi: 10.1021/jf062897a. PubMed DOI

Kallio H., Pallasaho S., Karppa J., Linko R.R. Comparison of the half-lives of the anthocyanins in the juice of crowberry, Empetrum nigrum. J. Food Sci. 1986;51:408–410. doi: 10.1111/j.1365-2621.1986.tb11142.x. DOI

Aruoma O.I., Cuppet S.L., editors. Antioxidant Methodology: In Vivo and In Vitro Concepts. AOCS Press; Champaign, IL, USA: 1997. p. 241.

Akasbi M., Shoeman W.D., Csallany A.S. High performance liquid chromatography of selected phenolic compounds in olive oils. J. Am. Oil Chem. Soc. 1993;70:367–370. doi: 10.1007/BF02552708. DOI

Gazdik Z., Reznicek V., Adam V., Zitka O., Jurikova T., Krska B., Matuskovic J., Plsek J., Saloun J., Horna A., et al. Use of Liquid Chromatography with Electrochemical Detection for the Determination of Antioxidants in Less Common Fruits. Molecules. 2008;13:2823–2836. doi: 10.3390/molecules131102823. PubMed DOI PMC

Gazdik Z., Zitka O., Reznicek V., Adam V., Krska B., Plsek J., Jurikova T., Saloun J., Babula P., Kizek R. Utilization of HPLC-ED techniques for the screening of functional foods from resources of biodiversity. Agriculture. 2009;55:80–87.

Sochor J., Ryvolova M., Krystofova O., Salas P., Hubalek J., Adam V., Trnkova L., Havel L., Beklova M., Zehnalek J., et al. Fully automated spectrometric protocols for determination of antioxidant activity: Advantages and disadvantages. Molecules. 2010;15:8618–8640. doi: 10.3390/molecules15128618. PubMed DOI PMC

Kim K.C., Lee I.K., Kang K.A., Kim D., Moon J.Y., Yoo B.S., Hyun J.W. Empetrum nigrum var. japonicum extract suppresses γ-ray radiation-induced cell damage via inhibition of oxidative stress. Am. J. Chin. Med. 2011;39:161–170. doi: 10.1142/S0192415X11008725. PubMed DOI

Kim K.C., Kim D., Kim S.C., Jung E., Park D., Hyun J.W. Empetrum nigrum var. japonicum extract suppresses ultraviolet B-induced cell damage via absorption of radiation and inhibition of oxidative stress. Evid. Based Complement. Altern. Med. 2013:983609. PubMed PMC

Halvorsen B.L., Carlsen M.H., Phillips K.M., Bøhn S.K., Holte K., Jacobs D.R., Jr., Blomhoff R. Content of redox-active compounds in foods consumed in US. Am. J. Clin. Nutr. 2006;84:95–135. PubMed

Ermilova E.V., Kadyrova T.V., Krasnov E.A., Khazanov V.A., Il'yushenko S.V., Pisareva S.I. Dense crowberry extract: Production technology, antioxidant and antihypoxant activity. Pharma.Chem. J. 2011;35:610–612. doi: 10.1023/A:1015197827847. DOI

Park S.Y., Lee S.P. Effectiveness of crowberry on plasma total antioxidant status, lipid profile and homocysteine. J. Food Nutr. Res. 2013;1:37–41.

Matsuura H., Saxena G., Farmer S.W., Hancock R.E., Towers G.H. Antibacterial and antifungal compounds from Empetrum nigrum. Planta Med. 1995;61:256–269. doi: 10.1055/s-2006-959382. PubMed DOI

Liisa J.N., Alakomi H.L., Kähkönen M.P., Heinonen M., Helander I.M., Oksman-Caldentey K.M., Puupponen-Pimiä R.H. Berry phenolics: Antimicrobial properties and mechanisms of action against severe human pathogens. Nutr. Cancer. 2006;54:18–32. PubMed

Rauha J.P., Remes S., Heinonen M., Hopia A., Kähkönen M. Antimicrobial effects of finnish plant extracts containing flavonoids and other phenolic compounds. Int. J. Food Microbiol. 2000;56:3–12. doi: 10.1016/S0168-1605(00)00218-X. PubMed DOI

Paudel A., Kaneko K., Watanabe A., Shigeki M., Motomu K., Hamamoto H. Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents. J. Antibiot. 2014;67:663–667. doi: 10.1038/ja.2013.137. PubMed DOI

Huttunen S., Toivanen M., Arkko S., Ruponen M., Tikkanen-Kaukanen C. Inhibition activity of wild berry juice fractions against Streptococcus pneumoniae binding to human bronchial cells. Phytother. Res. 2011;25:122–127. doi: 10.1002/ptr.3240. PubMed DOI

Gordien A.Y., Gray A.I., Ingleby K., Franzblau S.G., Seidel V. Activity of scottish plant, lichen and fungal endophyte extracts against mycobacterium aurum and mycobacterium tuberculosis. Phytother. Res. 2010;24:692–698. PubMed

Krasnov E.A., Ermilova E.V., Kadyrova T.V., Raldugin V.A., Bagryanskaya I.Y., Gatilov Y.V., Druganov A.G., Semenov A.A., Tolstikov G.A. Phenolic components of Empetrum nigrum extract and the crystal structure of one of them. Chem. Nat. Compd. 2000;36:493–496. doi: 10.1023/A:1002887406817. DOI

Li H., Jean S., Webster D., Robichaud G.A., Calhoun L.A., Johnson J.A., Gray C.A. Dibenz[b,f]oxepin and antimycobacterial chalcone constituents of Empetrum nigrum. J. Nat. Prod. 2015;78:2837–2840. doi: 10.1021/acs.jnatprod.5b00627. PubMed DOI

Heinonen I.M., Meyer A.S., Frankel E.N. Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidation. J. Agric. Food Chem. 1998;46:4107–4112. doi: 10.1021/jf980181c. DOI

Eiro M., Hopia A., Kaukovirta-Norja A., Lehtinen P., Heinonen M. Enhancing the colour of blackcurrant wine by natural additives. Vitic. Enol. Sci. 2000;55:3–6.

Eiro M.J., Heinonen M. Anthocyanin colour behavior and stability during storage: Effect on intermolecular copigmentation. J. Agric. Food Chem. 2002;50:7461–7466. doi: 10.1021/jf0258306. PubMed DOI

Rein M.J., Heinonen M. Stability and enhancement of berry juice colour. J. Agric. Food Chem. 2004;52:3106–3114. doi: 10.1021/jf035507i. PubMed DOI

Shaddi F., Alasalvar C., editors. Handbook of Functional Beverages and Human Health. CRC Press; Boca Raton, FL, USA: 2016. p. 860.

Najít záznam

Citační ukazatele

Nahrávání dat ...

    Možnosti archivace