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TRP-1 expression correlates with eumelanogenesis in human pigment cells in culture
Marmol V del, S Ito, I Jackson, J Vachtenheim, P Berr, G Ghanem, R Morandini, K Wakamatsu, G Huez
Jazyk angličtina Země Nizozemsko
Typ dokumentu práce podpořená grantem
Grantová podpora
IZ952
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
NLK
Free Medical Journals
od 1968 do 2015
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
PubMed
8348959
Knihovny.cz E-zdroje
- MeSH
- jednovláknová DNA MeSH
- kultivované buňky MeSH
- lidé MeSH
- melaniny * biosyntéza metabolismus MeSH
- melanocyty enzymologie metabolismus MeSH
- melanom * metabolismus MeSH
- membránové glykoproteiny * MeSH
- messenger RNA metabolismus MeSH
- molekulární sekvence - údaje MeSH
- nádorové buňky kultivované MeSH
- oxidoreduktasy * MeSH
- proteiny genetika metabolismus MeSH
- sekvence nukleotidů MeSH
- tyrosinasa genetika metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.
Dept Molecular Biology Universite Libre de Bruxelles Belgium
LOCE Faculty of Medicine Universite Libre de Bruxelles Belgium
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- $a We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.
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