-
Je něco špatně v tomto záznamu ?
ADMA, SDMA and L-arginine/ADMA ratio but not DDAH genetic polymorphisms are reliable predictors of diabetic nephropathy progression as identified by competing risk analysis
V. Tanhäuserová, J. Tomandl, L. Pácal, M. Klepárník, D. Malúšková, V. Bartáková, K. Kuricová, J. Rehořová, S. Stěpánková, J. Svojanovský, J. Olšovský, J. Bělobrádková, D. Krusová, M. Jurajda, J. Mužík, T. Pavlík, K. Kaňková,
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NT11405
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
ProQuest Central od 1994-05-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2005-01-01
Health & Medicine (ProQuest) od 1994-05-01 do Před 1 rokem
ROAD: Directory of Open Access Scholarly Resources od 1996
Odkazy
PubMed
23147199
DOI
10.1159/000343409
Knihovny.cz E-zdroje
- MeSH
- amidohydrolasy genetika MeSH
- arginin analogy a deriváty krev genetika MeSH
- diabetes mellitus 1. typu komplikace MeSH
- diabetes mellitus 2. typu komplikace MeSH
- diabetické nefropatie * krev etiologie genetika MeSH
- dospělí MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- metylace MeSH
- multivariační analýza MeSH
- následné studie MeSH
- prediktivní hodnota testů MeSH
- prognóza MeSH
- progrese nemoci * MeSH
- průřezové studie MeSH
- reprodukovatelnost výsledků MeSH
- rizikové faktory MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
BACKGROUND/AIMS: Complex interplay of genetic and (patho)physiological factors influence availability of nitric oxide during the development and progression of diabetic complications. We assessed predictive value of commonly studied methylated asymmetric and symmetric dimethylarginines (ADMA and SDMA) and selected single nucleotide polymorphisms (SNPs) in dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes for the progression of diabetic nephropathy (DN). METHODS: A total of 341 type 1 and type 2 diabetes patients with variable degree of kidney disease were included at baseline. Plasma levels of ADMA, SDMA and L-arginine were measured and six tagging SNPs in DDAH1 and 2 were determined. Progression of DN was defined as a transition from any given stage to a more advanced stage of albuminuria. Competing risk analysis was applied. RESULTS: Plasma levels of ADMA and SDMA significantly correlated with GFR. No significant genotype-phenotype relationship was ascertained for ADMA and DDAH variants, but SNP rs805304 exhibited marginally significant association with DN. ADMA, SDMA and L-arginine/ADMA ratio standardised to GFR were identified as significant predictors of DN progression but not GFR decline using multivariate competing risk analysis. CONCLUSIONS: In our study we confirmed potentially significant role of ADMA and SDMA for the assessment of risk of DN progression in European diabetic population.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc14040982
- 003
- CZ-PrNML
- 005
- 20190611093800.0
- 007
- ta
- 008
- 140107s2012 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1159/000343409 $2 doi
- 035 __
- $a (PubMed)23147199
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Tanhäuserová, Veronika $7 _AN049374 $u Dept. of Pathophysiology, Masaryk University Brno, Czech Republic
- 245 10
- $a ADMA, SDMA and L-arginine/ADMA ratio but not DDAH genetic polymorphisms are reliable predictors of diabetic nephropathy progression as identified by competing risk analysis / $c V. Tanhäuserová, J. Tomandl, L. Pácal, M. Klepárník, D. Malúšková, V. Bartáková, K. Kuricová, J. Rehořová, S. Stěpánková, J. Svojanovský, J. Olšovský, J. Bělobrádková, D. Krusová, M. Jurajda, J. Mužík, T. Pavlík, K. Kaňková,
- 520 9_
- $a BACKGROUND/AIMS: Complex interplay of genetic and (patho)physiological factors influence availability of nitric oxide during the development and progression of diabetic complications. We assessed predictive value of commonly studied methylated asymmetric and symmetric dimethylarginines (ADMA and SDMA) and selected single nucleotide polymorphisms (SNPs) in dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes for the progression of diabetic nephropathy (DN). METHODS: A total of 341 type 1 and type 2 diabetes patients with variable degree of kidney disease were included at baseline. Plasma levels of ADMA, SDMA and L-arginine were measured and six tagging SNPs in DDAH1 and 2 were determined. Progression of DN was defined as a transition from any given stage to a more advanced stage of albuminuria. Competing risk analysis was applied. RESULTS: Plasma levels of ADMA and SDMA significantly correlated with GFR. No significant genotype-phenotype relationship was ascertained for ADMA and DDAH variants, but SNP rs805304 exhibited marginally significant association with DN. ADMA, SDMA and L-arginine/ADMA ratio standardised to GFR were identified as significant predictors of DN progression but not GFR decline using multivariate competing risk analysis. CONCLUSIONS: In our study we confirmed potentially significant role of ADMA and SDMA for the assessment of risk of DN progression in European diabetic population.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a amidohydrolasy $x genetika $7 D000581
- 650 _2
- $a arginin $x analogy a deriváty $x krev $x genetika $7 D001120
- 650 _2
- $a průřezové studie $7 D003430
- 650 _2
- $a diabetes mellitus 1. typu $x komplikace $7 D003922
- 650 _2
- $a diabetes mellitus 2. typu $x komplikace $7 D003924
- 650 12
- $a diabetické nefropatie $x krev $x etiologie $x genetika $7 D003928
- 650 12
- $a progrese nemoci $7 D018450
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a následné studie $7 D005500
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a metylace $7 D008745
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a multivariační analýza $7 D015999
- 650 _2
- $a jednonukleotidový polymorfismus $x genetika $7 D020641
- 650 _2
- $a prediktivní hodnota testů $7 D011237
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a reprodukovatelnost výsledků $7 D015203
- 650 _2
- $a rizikové faktory $7 D012307
- 651 _2
- $a Česká republika $7 D018153
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Tomandl, Josef, $u - $d 1964- $7 mzk2003175507
- 700 1_
- $a Pácal, Lukáš $u - $7 xx0084072
- 700 1_
- $a Klepárník, Martin $u - $7 xx0237043
- 700 1_
- $a Krejčí, Denisa $u - $7 xx0232798
- 700 1_
- $a Bartáková, Vendula $u - $7 xx0240193
- 700 1_
- $a Chalásová, Katarína $u - $7 mub2017949800
- 700 1_
- $a Řehořová, Jitka $u -
- 700 1_
- $a Štěpánková, Soňa, $u - $d 1964- $7 xx0106210
- 700 1_
- $a Svojanovský, Jan $u - $7 xx0103906
- 700 1_
- $a Olšovský, Jindřich, $u - $d 1962- $7 nlk20060173684
- 700 1_
- $a Bělobrádková, Jana $u - $7 mzk2007382258
- 700 1_
- $a Krusová, Darja $u - $7 xx0143317
- 700 1_
- $a Jurajda, Michal, $u - $d 1971- $7 xx0037784
- 700 1_
- $a Mužík, Jan $u - $7 xx0133377
- 700 1_
- $a Pavlík, Tomáš $u - $7 xx0093293
- 700 1_
- $a Kaňková, Kateřina, $u - $d 1971- $7 mzk2003190820
- 773 0_
- $w MED00003064 $t Kidney & blood pressure research $x 1423-0143 $g Roč. 36, č. 1 (2012), s. 200-208
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/23147199 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20140107 $b ABA008
- 991 __
- $a 20190611093944 $b ABA008
- 999 __
- $a ok $b bmc $g 1005378 $s 839494
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2012 $b 36 $c 1 $d 200-208 $i 1423-0143 $m Kidney & blood pressure research $n Kidney Blood Press Res $x MED00003064
- GRA __
- $a NT11405 $p MZ0
- LZP __
- $a Pubmed-20140107