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Nitrite contamination in hypotensive preparations of dinitrosyl iron complexes with glutathine
Rostislav Romanovich Borodulin, Vyacheslav Olegovich Shvydkiy, Lyudmila Nikolaevna Kubrina, Vasak Dzhanibekovich Mikoyan, Natalya Ilinishna Zaitseva, Tatyana Evgenjevna Sporyagina, Sergey Alexandrovich Kryuchkov, Anatoly Fjodorovich Vanin
Jazyk angličtina Země Česko
Typ dokumentu práce podpořená grantem
NLK
Free Medical Journals
od 2003 do 2013
Freely Accessible Science Journals
od 2003 do 2013
ROAD: Directory of Open Access Scholarly Resources
od 2002
- MeSH
- antihypertenziva * farmakologie MeSH
- dusičnany farmakologie MeSH
- farmaceutická chemie metody přístrojové vybavení MeSH
- kontaminace léku * MeSH
- lidé MeSH
- oxidy dusíku farmakologie MeSH
- S-nitrosoglutathion farmakologie MeSH
- sloučeniny dusíku * farmakologie MeSH
- spektrofotometrie metody přístrojové vybavení využití MeSH
- statistika jako téma MeSH
- vazodilatancia farmakologie MeSH
- vysokoúčinná kapalinová chromatografie metody přístrojové vybavení využití MeSH
- železo farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
The content of nitrite admixture in preparations of dinitrosyl iron complexes (DNIC) with glutathione synthesized by treatment of aqueous solutions of Fe2+ + glutathione with gaseous NO (complex 1) or by mixing solutions of S-nitrosoglutathione (GS-NO) with solutions of Fe2+ + glutathione (complex 2) was determined using the Griess method and HPLC as well as from the level of HNO2 formed upon interaction of gaseous NO with acidified distilled water. In both preparations, DNIC were predominantly represented by the binuclear form (B-DNIC). In complex 1, the appearance of nitrite in DNIC solutions was induced by nitrogen dioxide present in gaseous NO; its interaction with NO gives an adduct, which is further hydrolyzed to nitrite in aqueous solutions. In complex 2, the presence of nitrite admixture could appear in the presence of nitrite non-incorporated into GS-NO synthesized by mixing glutathione and nitrite in acid media. The per cent content of nitrite (with respect to the total content of complex 1) was 6%, whereas in complex 2 it was as low as 0.4%. Such a low level of nitrite contamination in the course of conventional synthesis of DNIC with glutathione does not make any significant contribution to their biomedical (e.g., hypotensive or vasodilator) activity.
Citace poskytuje Crossref.org
Literatura
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- $a The content of nitrite admixture in preparations of dinitrosyl iron complexes (DNIC) with glutathione synthesized by treatment of aqueous solutions of Fe2+ + glutathione with gaseous NO (complex 1) or by mixing solutions of S-nitrosoglutathione (GS-NO) with solutions of Fe2+ + glutathione (complex 2) was determined using the Griess method and HPLC as well as from the level of HNO2 formed upon interaction of gaseous NO with acidified distilled water. In both preparations, DNIC were predominantly represented by the binuclear form (B-DNIC). In complex 1, the appearance of nitrite in DNIC solutions was induced by nitrogen dioxide present in gaseous NO; its interaction with NO gives an adduct, which is further hydrolyzed to nitrite in aqueous solutions. In complex 2, the presence of nitrite admixture could appear in the presence of nitrite non-incorporated into GS-NO synthesized by mixing glutathione and nitrite in acid media. The per cent content of nitrite (with respect to the total content of complex 1) was 6%, whereas in complex 2 it was as low as 0.4%. Such a low level of nitrite contamination in the course of conventional synthesis of DNIC with glutathione does not make any significant contribution to their biomedical (e.g., hypotensive or vasodilator) activity.
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