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Nitrite contamination in hypotensive preparations of dinitrosyl iron complexes with glutathine
Rostislav Romanovich Borodulin, Vyacheslav Olegovich Shvydkiy, Lyudmila Nikolaevna Kubrina, Vasak Dzhanibekovich Mikoyan, Natalya Ilinishna Zaitseva, Tatyana Evgenjevna Sporyagina, Sergey Alexandrovich Kryuchkov, Anatoly Fjodorovich Vanin
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 2003 to 2013
Freely Accessible Science Journals
from 2003 to 2013
ROAD: Directory of Open Access Scholarly Resources
from 2002
- MeSH
- Antihypertensive Agents * pharmacology MeSH
- Nitrates pharmacology MeSH
- Chemistry, Pharmaceutical methods instrumentation MeSH
- Drug Contamination * MeSH
- Humans MeSH
- Nitrogen Oxides pharmacology MeSH
- S-Nitrosoglutathione pharmacology MeSH
- Nitrogen Compounds * pharmacology MeSH
- Spectrophotometry methods instrumentation utilization MeSH
- Statistics as Topic MeSH
- Vasodilator Agents pharmacology MeSH
- Chromatography, High Pressure Liquid methods instrumentation utilization MeSH
- Iron pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
The content of nitrite admixture in preparations of dinitrosyl iron complexes (DNIC) with glutathione synthesized by treatment of aqueous solutions of Fe2+ + glutathione with gaseous NO (complex 1) or by mixing solutions of S-nitrosoglutathione (GS-NO) with solutions of Fe2+ + glutathione (complex 2) was determined using the Griess method and HPLC as well as from the level of HNO2 formed upon interaction of gaseous NO with acidified distilled water. In both preparations, DNIC were predominantly represented by the binuclear form (B-DNIC). In complex 1, the appearance of nitrite in DNIC solutions was induced by nitrogen dioxide present in gaseous NO; its interaction with NO gives an adduct, which is further hydrolyzed to nitrite in aqueous solutions. In complex 2, the presence of nitrite admixture could appear in the presence of nitrite non-incorporated into GS-NO synthesized by mixing glutathione and nitrite in acid media. The per cent content of nitrite (with respect to the total content of complex 1) was 6%, whereas in complex 2 it was as low as 0.4%. Such a low level of nitrite contamination in the course of conventional synthesis of DNIC with glutathione does not make any significant contribution to their biomedical (e.g., hypotensive or vasodilator) activity.
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Literatura
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- $a The content of nitrite admixture in preparations of dinitrosyl iron complexes (DNIC) with glutathione synthesized by treatment of aqueous solutions of Fe2+ + glutathione with gaseous NO (complex 1) or by mixing solutions of S-nitrosoglutathione (GS-NO) with solutions of Fe2+ + glutathione (complex 2) was determined using the Griess method and HPLC as well as from the level of HNO2 formed upon interaction of gaseous NO with acidified distilled water. In both preparations, DNIC were predominantly represented by the binuclear form (B-DNIC). In complex 1, the appearance of nitrite in DNIC solutions was induced by nitrogen dioxide present in gaseous NO; its interaction with NO gives an adduct, which is further hydrolyzed to nitrite in aqueous solutions. In complex 2, the presence of nitrite admixture could appear in the presence of nitrite non-incorporated into GS-NO synthesized by mixing glutathione and nitrite in acid media. The per cent content of nitrite (with respect to the total content of complex 1) was 6%, whereas in complex 2 it was as low as 0.4%. Such a low level of nitrite contamination in the course of conventional synthesis of DNIC with glutathione does not make any significant contribution to their biomedical (e.g., hypotensive or vasodilator) activity.
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