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Features of balance of proinflammatory and anti-inflammatory cytokines in newborns with herpes virus infections
Zukhra Rakhmankulova
Language English Country Czech Republic
- MeSH
- Cytokines * blood MeSH
- Cytomegalovirus Infections MeSH
- Fetal Blood immunology MeSH
- Herpes Simplex MeSH
- Pregnancy Complications, Infectious * MeSH
- Interferon-gamma blood MeSH
- Interleukin-1beta blood MeSH
- Interleukin-4 blood MeSH
- Interleukin-8 blood MeSH
- Humans MeSH
- Infant, Newborn immunology blood MeSH
- Case-Control Studies MeSH
- Pregnancy MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn immunology blood MeSH
- Pregnancy MeSH
- Female MeSH
The paper examines features of balance between proinflammatory and anti-inflammatory cytokines in newborns of mothers with herpes virus infections (SHV, CMVI). This investigation included 35 newborns, of them 10 were full-term newborns of healthy mothers (group 1 - umbilical blood); 10 - full-term newborns with various pathology of perinatal period in mothers with intrauterine infections (group 2 - umbilical blood); 15 practically healthy newborns of healthy mothers (control group - peripheral blood). The paper studies production of proinflammatory IL-1b, IL-8, γ-IFN and anti-inflammatory (IL-4) cytokines in newborns in norm and with intrauterine infections. The study has shown that the level IL-4 in the umbilical blood in newborns born from the mothers with intrauterine infection did not differ from a level in peripheral blood of healthy newborns. It has found also that there was 1.5 times increase of IL-1b in newborns with intrauterine infection in the umbilical blood in comparison with umbilical blood in healthy newborns, 3.4 times increase in IL-8 and the tendency to increase IFN-gamma.
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Literatura
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- $a Rakhmankulova, Zukhra $u Institute of Immunology Academy of Sciences, Tashkent Pediatric Medical Institute, Uzbekistan
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- $a Features of balance of proinflammatory and anti-inflammatory cytokines in newborns with herpes virus infections / $c Zukhra Rakhmankulova
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- $a The paper examines features of balance between proinflammatory and anti-inflammatory cytokines in newborns of mothers with herpes virus infections (SHV, CMVI). This investigation included 35 newborns, of them 10 were full-term newborns of healthy mothers (group 1 - umbilical blood); 10 - full-term newborns with various pathology of perinatal period in mothers with intrauterine infections (group 2 - umbilical blood); 15 practically healthy newborns of healthy mothers (control group - peripheral blood). The paper studies production of proinflammatory IL-1b, IL-8, γ-IFN and anti-inflammatory (IL-4) cytokines in newborns in norm and with intrauterine infections. The study has shown that the level IL-4 in the umbilical blood in newborns born from the mothers with intrauterine infection did not differ from a level in peripheral blood of healthy newborns. It has found also that there was 1.5 times increase of IL-1b in newborns with intrauterine infection in the umbilical blood in comparison with umbilical blood in healthy newborns, 3.4 times increase in IL-8 and the tendency to increase IFN-gamma.
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