• Je něco špatně v tomto záznamu ?

Role of peroxisome proliferator-activated receptors δ (PPARδ) in rats showing endotoxemic heart failure

Ping-Chin Chang, Li-Jen Chen, Juei-Tang Cheng

. 2014 ; 12 (2) : 79-85.

Jazyk angličtina Země Česko

Typ dokumentu práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc14065922

PPARδ-dependent maintenance of inotropic function is mentioned as crucial for cardiomyocytes. However, change of PPARδ in endotoxins-induced cardiac dysfunction is still unclear. The present study is then designed to investigate the changes of PPARδ in rats showing LPS-induced cardiac dysfunction. In the in vivo experiments, adult Wistar rats were treated with intravenous injection of 10 mg/kg LPS for 6 h. The isolated heart determined in Langendorff apparatus and the hemodynamic analysis of rats used to measure the changes of cardiac function extra vivo and in vivo. We found that LPS decreased the cardiac contractility in isolated heart and lowered the hemodynamic dP/dtmax in rats. Also, this action of LPS was reversed by PPARδ agonist. In cultured neonatal rat cardiac cells incubated with LPS, the intracellular calcium concentration and troponin I phosphorylation were both reduced after the detection of intracellular calcium level and Western blotting analysis. PPARδ agonist also reversed both actions of LPS in cardiomyocyte. The obtained results suggest that LPS induced decreases in PPARδ expression and troponin I phosphorylation to result in acute heart failure similar to cardiac dysfunction in endotoxemia.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc14065922
003      
CZ-PrNML
005      
20140916105303.0
007      
ta
008      
140721s2014 xr d f 000 0eng||
009      
AR
024    7_
$a 10.1016/j.jab.2013.05.001 $2 doi
040    __
$a ABA008 $d ABA008 $e AACR2 $b cze
041    0_
$a eng
044    __
$a xr
100    1_
$a Chang, Ping-Chin $u Department of Infection, Chi-Mei Medical Center Liouying, Liou-Ying, Tainan City, Taiwan
245    10
$a Role of peroxisome proliferator-activated receptors δ (PPARδ) in rats showing endotoxemic heart failure / $c Ping-Chin Chang, Li-Jen Chen, Juei-Tang Cheng
504    __
$a Literatura
520    3_
$a PPARδ-dependent maintenance of inotropic function is mentioned as crucial for cardiomyocytes. However, change of PPARδ in endotoxins-induced cardiac dysfunction is still unclear. The present study is then designed to investigate the changes of PPARδ in rats showing LPS-induced cardiac dysfunction. In the in vivo experiments, adult Wistar rats were treated with intravenous injection of 10 mg/kg LPS for 6 h. The isolated heart determined in Langendorff apparatus and the hemodynamic analysis of rats used to measure the changes of cardiac function extra vivo and in vivo. We found that LPS decreased the cardiac contractility in isolated heart and lowered the hemodynamic dP/dtmax in rats. Also, this action of LPS was reversed by PPARδ agonist. In cultured neonatal rat cardiac cells incubated with LPS, the intracellular calcium concentration and troponin I phosphorylation were both reduced after the detection of intracellular calcium level and Western blotting analysis. PPARδ agonist also reversed both actions of LPS in cardiomyocyte. The obtained results suggest that LPS induced decreases in PPARδ expression and troponin I phosphorylation to result in acute heart failure similar to cardiac dysfunction in endotoxemia.
650    _2
$a zvířata $7 D000818
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Wistar $7 D017208
650    _2
$a mužské pohlaví $7 D008297
650    12
$a receptory aktivované proliferátory peroxizomů $x účinky léků $7 D047492
650    12
$a srdeční selhání $x patologie $7 D006333
650    _2
$a thiazoly $x aplikace a dávkování $7 D013844
650    12
$a lipopolysacharidy $x aplikace a dávkování $7 D008070
650    12
$a endotoxemie $x farmakoterapie $7 D019446
650    _2
$a western blotting $7 D015153
650    _2
$a kultivační techniky $7 D046508
650    _2
$a statistika jako téma $7 D013223
650    _2
$a krevní tlak $x účinky léků $7 D001794
650    _2
$a troponin I $x metabolismus $7 D019210
650    _2
$a intracelulární "calcium-sensing" proteiny $7 D052139
650    _2
$a kardiomyocyty $x metabolismus $x patologie $x účinky léků $7 D032383
650    _2
$a novorozená zvířata $7 D000831
650    _2
$a kontrakce myokardu $x účinky léků $7 D009200
650    _2
$a hemodynamika $x účinky léků $7 D006439
653    00
$a GW0742
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Chen, Li-Jen $u Graduate Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
700    1_
$a Cheng, Juei-Tang $u Department of Medical Research, Chi-Mei Medical Center, Yong Kang City, Tiwan
773    0_
$t Journal of applied biomedicine $x 1214-021X $g Roč. 12, č. 2 (2014), s. 79-85 $w MED00012667
856    41
$u https://jab.zsf.jcu.cz/pdfs/jab/2014/02/03.pdf $y plný text volně přístupný
910    __
$a ABA008 $b B 2301 $c 1249 $y 4 $z 0
990    __
$a 20140721124002 $b ABA008
991    __
$a 20140916105713 $b ABA008
999    __
$a ok $b bmc $g 1033400 $s 864698
BAS    __
$a 3
BMC    __
$a 2014 $b 12 $c 2 $d 79-85 $i 1214-021X $m Journal of Applied Biomedicine $n J. Appl. Biomed. (Čes. Budějovice Print) $x MED00012667
LZP    __
$c NLK188 $d 20140916 $a NLK 2014-15/mk

Najít záznam

Citační ukazatele

Možnosti archivace