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The cell survival function of JNK

Qing-Hua Wu, Zong-Hui Yuan, Xiu-Juan Zhang

. 2014 ; 83 (1) : 28-33.

Jazyk angličtina Země Česko

Typ dokumentu práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc14071328

c-Jun N-terminal kinases (JNK) can be activated by multiple environmental stress, leading to varied and contradictory cellular response. JNK mediates cell apoptosis as well as cell survival and proliferation. JNK1 and JNK2 as the major members are able to perform similar and distinct biological functions. This review mainly discussed the mechanism of JNK cell survival function and the distinct roles of JNK1 and JNK2 in cell apoptosis and proliferation. Transient JNK activation may be important for mediating a survival response in TNF-treated cells and chronic JNK activation may contribute to apoptotic response. Other signal transduction pathways may also participate in its protective function. Abrogation of p38 MAPK pathway is assumed to induce pro-survival role. JNK suppresses apoptosis via phosphorylation of the pro-apoptotic Bcl-2 family protein BAD. Activated JNK inactivates suppressors of the apoptotic machinery, thereby “breaking the brake” on apoptosis.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

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