• Je něco špatně v tomto záznamu ?

Vulvovaginal angiomyofibroblastomas: morphologic, immunohistochemical, and fluorescence in situ hybridization analysis for deletion of 13q14 region

G. Magro, A. Righi, R. Caltabiano, L. Casorzo, M. Michal,

. 2014 ; 45 (8) : 1647-55.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc14074161

Angiomyofibroblastoma (AMFB) is a benign tumor that belongs to the category of the "stromal tumors of the lower female genital tract," together with cellular angiofibroma and myofibroblastoma. Previous studies have shown overlapping morphologic and immunohistochemical features between these tumors and spindle cell lipoma, mammary-type myofibroblastoma, and vulvovaginal cellular angiofibroma and myofibroblastoma. In addition, typical loss of genetic material from the 13q14 region has been documented in all the above-mentioned tumors, suggesting that they are histogenetically related. We report the clinicopathologic features of 11 new cases of vulvovaginal AMFBs. Histologically, the basic common theme was a proliferation of bland-looking spindle to round-to-epithelioid cells set in an edematous to fibrous stroma, frequently arranged around thin-walled blood vessels. Two cases were composed of a prominent mature fatty component closely admixed with typical areas of AMFB, and thus, they were designated as "lipomatous AMFBs." Notably, 1 case was closely reminiscent of Sertoli cell tumor, sclerosing type, because of its predominant cord-like arrangement. Immunohistochemically, all tumors were diffusely positive for vimentin, whereas desmin and α-smooth muscle actin were expressed in a minority of cases, suggesting a fibroblastic rather than myofibroblastic differentiation. Most cases of AMFBs coexpressed Bcl-2 protein and CD99. Interestingly, all 5 cases of AMFB with evaluable signals failed to show monoallelic loss of FOXO1 loci (13q14) by fluorescence in situ hybridization. These cytogenetic findings suggest that vulvovaginal AMFB is not genetically related to cellular angiofibroma and myofibroblastoma of the lower female genital tract.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc14074161
003      
CZ-PrNML
005      
20141008122632.0
007      
ta
008      
141006s2014 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.humpath.2014.03.020 $2 doi
035    __
$a (PubMed)24880711
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Magro, Gaetano $u Department G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele" Anatomic Pathology, University of Catania, 95123 Catania, Italy. Electronic address: g.magro@unict.it.
245    10
$a Vulvovaginal angiomyofibroblastomas: morphologic, immunohistochemical, and fluorescence in situ hybridization analysis for deletion of 13q14 region / $c G. Magro, A. Righi, R. Caltabiano, L. Casorzo, M. Michal,
520    9_
$a Angiomyofibroblastoma (AMFB) is a benign tumor that belongs to the category of the "stromal tumors of the lower female genital tract," together with cellular angiofibroma and myofibroblastoma. Previous studies have shown overlapping morphologic and immunohistochemical features between these tumors and spindle cell lipoma, mammary-type myofibroblastoma, and vulvovaginal cellular angiofibroma and myofibroblastoma. In addition, typical loss of genetic material from the 13q14 region has been documented in all the above-mentioned tumors, suggesting that they are histogenetically related. We report the clinicopathologic features of 11 new cases of vulvovaginal AMFBs. Histologically, the basic common theme was a proliferation of bland-looking spindle to round-to-epithelioid cells set in an edematous to fibrous stroma, frequently arranged around thin-walled blood vessels. Two cases were composed of a prominent mature fatty component closely admixed with typical areas of AMFB, and thus, they were designated as "lipomatous AMFBs." Notably, 1 case was closely reminiscent of Sertoli cell tumor, sclerosing type, because of its predominant cord-like arrangement. Immunohistochemically, all tumors were diffusely positive for vimentin, whereas desmin and α-smooth muscle actin were expressed in a minority of cases, suggesting a fibroblastic rather than myofibroblastic differentiation. Most cases of AMFBs coexpressed Bcl-2 protein and CD99. Interestingly, all 5 cases of AMFB with evaluable signals failed to show monoallelic loss of FOXO1 loci (13q14) by fluorescence in situ hybridization. These cytogenetic findings suggest that vulvovaginal AMFB is not genetically related to cellular angiofibroma and myofibroblastoma of the lower female genital tract.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a angiofibrom $x genetika $x metabolismus $x patologie $7 D018322
650    _2
$a CD antigeny $x genetika $x metabolismus $7 D015703
650    _2
$a molekuly buněčné adheze $x genetika $x metabolismus $7 D015815
650    _2
$a chromozomální delece $7 D002872
650    _2
$a lidské chromozomy, pár 13 $7 D002882
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a imunohistochemie $7 D007150
650    _2
$a hybridizace in situ fluorescenční $7 D017404
650    _2
$a lidé středního věku $7 D008875
650    _2
$a nádory ze svalové tkáně $x genetika $x metabolismus $x patologie $7 D009379
650    _2
$a protoonkogenní proteiny c-bcl-2 $x genetika $x metabolismus $7 D019253
650    _2
$a nádory vaginy $x genetika $x metabolismus $x patologie $7 D014625
650    _2
$a vimentin $x genetika $x metabolismus $7 D014746
650    _2
$a nádory vulvy $x genetika $x metabolismus $x patologie $7 D014846
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Righi, Alberto $u Pathology Department, Rizzoli Institute, 40136 Bologna, Italy.
700    1_
$a Caltabiano, Rosario $u Department G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele" Anatomic Pathology, University of Catania, 95123 Catania, Italy.
700    1_
$a Casorzo, Laura $u Institute for Cancer Research and Treatment, 10060 Candiolo-Torino, Italy.
700    1_
$a Michal, Michal $u Sikl's Department of Pathology, Charles University Medical Faculty Hospital, 30460 Pilsen, Czech Republic.
773    0_
$w MED00002080 $t Human pathology $x 1532-8392 $g Roč. 45, č. 8 (2014), s. 1647-55
856    41
$u https://pubmed.ncbi.nlm.nih.gov/24880711 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20141006 $b ABA008
991    __
$a 20141008123020 $b ABA008
999    __
$a ok $b bmc $g 1042044 $s 873073
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 45 $c 8 $d 1647-55 $i 1532-8392 $m Human pathology $n Hum Pathol $x MED00002080
LZP    __
$a Pubmed-20141006

Najít záznam

Citační ukazatele

    Možnosti archivace