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Tumor protective activity of CD4+ but not of CD8+ T cells in DNA-vaccinated mice challenged with bcr-abl-transformed cells
M. Petráčková, V. Lučanský, V. Vonka,
Jazyk angličtina Země Egypt
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NT12363
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
Free Medical Journals od 1990
PubMed Central od 2003 do 2013
Europe PubMed Central od 2003 do 2013
Open Access Digital Library od 2003-01-01 do 2013-12-31
Open Access Digital Library od 2003-01-01 do 2013-12-31
Open Access Digital Library od 2003-01-01
Medline Complete (EBSCOhost) od 2003-03-01 do 2013-01-31
ROAD: Directory of Open Access Scholarly Resources od 2003 do 2013
Odkazy
PubMed
24348684
DOI
10.1155/2013/923107
Knihovny.cz E-zdroje
- MeSH
- antigeny CD95 imunologie metabolismus MeSH
- bcr-abl fúzové proteiny genetika imunologie MeSH
- CD4-pozitivní T-lymfocyty imunologie metabolismus MeSH
- CD8-pozitivní T-lymfocyty imunologie metabolismus MeSH
- DNA vakcíny imunologie MeSH
- histokompatibilita - antigeny třídy II imunologie metabolismus MeSH
- imunizace MeSH
- lidé MeSH
- ligand Fas metabolismus MeSH
- lymfocytární deplece MeSH
- modely nemocí na zvířatech MeSH
- myši MeSH
- nádorová transformace buněk genetika imunologie MeSH
- nádory genetika imunologie mortalita prevence a kontrola MeSH
- protinádorové vakcíny genetika imunologie MeSH
- slezina cytologie imunologie MeSH
- transformované buněčné linie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
In the recent past, it has repeatedly been reported that CD4 cells play an important role in the immunology of chronic myeloid leukaemia. It was therefore of interest to test their activity in an animal model using bcr-abl-transformed cells. BALB/c mice were four times immunized with a DNA vaccine carrying the bcr-abl fusion gene. Two weeks after the last vaccine dose, the animals were challenged with syngeneic bcr-abl-transformed 12B1 cells which form solid tumors after subcutaneous administration. At the time of challenge, animals were treated with antibodies against the CD8+ T cells or CD4+ T cells. The efficacy of the depletion was monitored and found highly effective. All nonimmunized animals developed tumors. All animals untreated with the antibodies as well as those in which CD8+ T cells had been depleted, were fully protected against the challenge. On the other hand, almost all mice treated with anti-CD4+ antibody developed tumors. These results strongly suggested that the CD4+ T cells acted as effectors in the present system.
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