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Lichen secondary metabolites as DNA-interacting agents
J. Plsíkova, J. Stepankova, J. Kasparkova, V. Brabec, M. Backor, M. Kozurkova,
Toxicology in vitro.
2014 ;
28 (2) :
182-6.
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc14074479
- MeSH
- benzoáty farmakologie MeSH
- benzofurany farmakologie MeSH
- cirkulární dichroismus MeSH
- DNA účinky léků metabolismus MeSH
- emodin analogy a deriváty farmakologie MeSH
- hydroxybenzoáty farmakologie MeSH
- inhibitory topoisomerasy I farmakologie MeSH
- inhibitory topoisomerasy II farmakologie MeSH
- interkalátory farmakologie MeSH
- kinetika MeSH
- konformace nukleové kyseliny MeSH
- lidé MeSH
- lišejníky chemie metabolismus MeSH
- skot MeSH
- spektrofotometrie ultrafialová MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
A series of lichen secondary metabolites (parietin, atranorin, usnic and gyrophoric acid) and their interactions with calf thymus DNA were investigated using molecular biophysics and biochemical methods. The binding constants K were estimated to range from 4.3×10(5) to 2.4×10(7)M(-1) and the percentage of hypochromism was found to be 16-34% (from spectral titration). The results of spectral measurement indicate that the compounds act as effective DNA-interacting agents. Electrophoretic separation studies prove that from all the metabolites tested in this study, only gyrophoric acid exhibited an inhibitory effect on Topo I (25μM).
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- $a A series of lichen secondary metabolites (parietin, atranorin, usnic and gyrophoric acid) and their interactions with calf thymus DNA were investigated using molecular biophysics and biochemical methods. The binding constants K were estimated to range from 4.3×10(5) to 2.4×10(7)M(-1) and the percentage of hypochromism was found to be 16-34% (from spectral titration). The results of spectral measurement indicate that the compounds act as effective DNA-interacting agents. Electrophoretic separation studies prove that from all the metabolites tested in this study, only gyrophoric acid exhibited an inhibitory effect on Topo I (25μM).
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- $a Stepankova, J $u Institute of Biophysics, Department of Molecular Biophysics and Pharmacology, Academy of Science of the Czech Republic, Brno, Czech Republic.
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