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Sperm and embryo analysis in a carrier of supernumerary inv dup(15) marker chromosome

Eva Oracova, Petra Musilova, Olga Kopecna, Roman Rybar, Miluse Vozdova, Katerina Vesela, Jiri Rubes

. 2009 ; 30 (3) : 233-239.

Language English Country United States

Document type Case Reports, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc14080265

Grant support
NS9842 MZ0 CEP Register

We identified a small, paternally inherited, supernumerary marker chromosome, inv dup(15), in a phenotypically normal and normozoospermic male from a couple with reproductive problems. Sperm analysis by fluorescence in situ hybridization (FISH) showed that the marker was present in 26% of sperm nuclei. The disomy 15 was 10 times higher than in normal control donors. FISH analysis for aneuploidies of the other chromosomes showed an increase in nondisjunction of chromosome 21. We also examined 24 embryos by preimplantation genetic diagnosis, and 10 embryos (41.7%) contained the marker. This report provides information about inheritance of inv dup(15) from a male carrier.

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