Sperm and embryo analysis in a carrier of supernumerary inv dup(15) marker chromosome
Language English Country United States Media print-electronic
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
PubMed
19059902
DOI
10.2164/jandrol.108.006783
PII: jandrol.108.006783
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Embryo, Mammalian MeSH
- Heterozygote MeSH
- In Situ Hybridization, Fluorescence MeSH
- Humans MeSH
- Chromosomes, Human, Pair 15 genetics MeSH
- Infertility, Male genetics MeSH
- Pedigree MeSH
- Spermatozoa * MeSH
- Pregnancy MeSH
- Uniparental Disomy genetics MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
We identified a small, paternally inherited, supernumerary marker chromosome, inv dup(15), in a phenotypically normal and normozoospermic male from a couple with reproductive problems. Sperm analysis by fluorescence in situ hybridization (FISH) showed that the marker was present in 26% of sperm nuclei. The disomy 15 was 10 times higher than in normal control donors. FISH analysis for aneuploidies of the other chromosomes showed an increase in nondisjunction of chromosome 21. We also examined 24 embryos by preimplantation genetic diagnosis, and 10 embryos (41.7%) contained the marker. This report provides information about inheritance of inv dup(15) from a male carrier.
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