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Human breast epithelial xenografts: an immunocytochemical and ultrastructural study of differentiation and lactogenic response
JD. Dubois, MJ. O'Hare, P. Monaghan, J. Bartek, R. Norris, BA. Gusterson,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
PubMed
2448180
Knihovny.cz E-zdroje
- MeSH
- aktiny analýza MeSH
- buněčná diferenciace MeSH
- buněčné jádro ultrastruktura MeSH
- chromatin ultrastruktura MeSH
- dospělí MeSH
- elektronová mikroskopie MeSH
- epitel ultrastruktura MeSH
- keratiny analýza MeSH
- kolagen analýza MeSH
- lidé MeSH
- monoklonální protilátky MeSH
- myši nahé MeSH
- myši MeSH
- prsy cytologie sekrece transplantace MeSH
- těhotenství MeSH
- transplantace heterologní MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- myši MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Fragments of ductal and lobular epithelium ('organoids') produced by collagenase digestion of reduction-mammoplasty specimens were injected into athymic 'nude' mice. These heterospecific tissues were accepted without rejection, and the presence of xenografts was confirmed by cytology, immunocytochemistry and chromatin staining. Lactation, as confirmed by immunocytochemical and ultrastructural criteria, was observed in the grafted human epithelium during murine pregnancy at both intra- and extra-mammary sites.
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- $a Fragments of ductal and lobular epithelium ('organoids') produced by collagenase digestion of reduction-mammoplasty specimens were injected into athymic 'nude' mice. These heterospecific tissues were accepted without rejection, and the presence of xenografts was confirmed by cytology, immunocytochemistry and chromatin staining. Lactation, as confirmed by immunocytochemical and ultrastructural criteria, was observed in the grafted human epithelium during murine pregnancy at both intra- and extra-mammary sites.
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