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No causal association identified for human papillomavirus infections in lung cancer

D. Anantharaman, T. Gheit, T. Waterboer, G. Halec, C. Carreira, B. Abedi-Ardekani, S. McKay-Chopin, D. Zaridze, A. Mukeria, N. Szeszenia-Dabrowska, J. Lissowska, D. Mates, V. Janout, L. Foretova, V. Bencko, P. Rudnai, E. Fabianova, A. Tjønneland,...

. 2014 ; 74 (13) : 3525-34.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15008087

Human papillomavirus (HPV) infections have been implicated in lung carcinogenesis, but causal associations remain uncertain. We evaluated a potential causal role for HPV infections in lung cancer through an analysis involving serology, tumor DNA, RNA, and p16 protein expression. Association between type-specific HPV antibodies and risk of lung cancer was examined among 3,083 cases and 4,328 controls in two case-control studies (retrospective) and one nested case-control study (prospective design). Three hundred and thirty-four available tumors were subjected to pathologic evaluation and subsequent HPV genotyping following stringent conditions to detect all high-risk and two low-risk HPV types. All HPV DNA-positive tumors were further tested for the expression of p16 protein and type-specific HPV mRNA. On the basis of the consistency of the results, although HPV11 and HPV31 E6 antibodies were associated with lung cancer risk in the retrospective study, no association was observed in the prospective design. Presence of type-specific antibodies correlated poorly with the presence of the corresponding HPV DNA in the tumor. Although nearly 10% of the lung tumors were positive for any HPV DNA (7% for HPV16 DNA), none expressed the viral oncogenes. No association was observed between HPV antibodies or DNA and lung cancer survival. In conclusion, we found no supportive evidence for the hypothesized causal association between HPV infections and lung cancer.

1st Department of Critical Care Medicine and Pulmonary Services University of Athens Medical School Evangelismos Hospital

Authors' Affiliations Genetic Epidemiology Group

Bureau of Epidemiologic Research Academy of Athens Athens Greece

Cancer Epidemiology Unit Nuffield Department of Clinical Medicine University of Oxford Oxford

Danish Cancer Society Research Center Copenhagen Denmark

Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno

Department of Community Medicine Faculty of Health Sciences The Artic University of Norway Tromsø

Department of Environmental Epidemiology Nofer Institute of Occupational Medicine Lodz

Department of Epidemiology and Prevention Russian Cancer Research Center Moscow Russia

Department of Epidemiology German Institute of Human Nutrition Potsdam Rehbruecke Nuthetal Germany

Department of Gastroenterology and Hepatology University Medical Centre Utrecht the Netherlands

Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden

Department of Preventive Medicine Palacky University Olomouc

Department of Radiation Sciences Oncology Umeå University Umeå

Department of Research Cancer Registry of Norway Oslo Norway

Digestive Disease Research Center Tehran University of Medical Sciences Tehran Iran

Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milano Italy

IGR Villejuif France

Infection and Cancer Program German Cancer Research Center Heidelberg

Infections and Cancer Biology Group

INSERM Centre for research in Epidemiology and Population Health U1018 Nutrition Hormones and Women's Health team

Institute of Hygiene and Epidemiology 1 Faculty of Medicine Charles University Prague Prague Czech Republic

Institute of Public Health Bucharest Romania

M Sklodowska Curie Memorial Cancer Center and Institute of Oncology Warsaw Poland

Molecular Pathology Group International Agency for Research on Cancer Lyon

National Institute for Public Health and the Environment Bilthoven

National Institute of Environmental Health Budapest Hungary

Public Health Directorate Asturias Spain

Regional Authority of Public Health Banská Bystrica Slovakia

Samfundet Folkhälsan Helsinki Finland

The School of Public health Imperial College London London United Kingdom

University Paris Sud

Citace poskytuje Crossref.org

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