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Granulocyte colony-stimulating factor in the treatment of acute radiation syndrome: a concise review
M. Hofer, M. Pospíšil, D. Komůrková, Z. Hoferová,
Language English Country Switzerland
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
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- MeSH
- Acute Radiation Syndrome drug therapy pathology MeSH
- Time Factors MeSH
- Granulocyte Colony-Stimulating Factor biosynthesis therapeutic use MeSH
- Interleukin-3 therapeutic use MeSH
- Drug Therapy, Combination MeSH
- Bone Marrow pathology radiation effects MeSH
- Humans MeSH
- Membrane Proteins therapeutic use MeSH
- Recombinant Proteins therapeutic use MeSH
- Drug Administration Schedule MeSH
- Stem Cell Factor therapeutic use MeSH
- Thrombopoietin therapeutic use MeSH
- Radioactive Hazard Release MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.
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- $a Hofer, Michal $u Department of Molecular Cytology and Cytometry, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, Brno CZ-612 65, Czech Republic. hofer@ibp.cz.
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- $a This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.
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- $a Hoferová, Zuzana $u Department of Molecular Cytology and Cytometry, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, Brno CZ-612 65, Czech Republic. hoferovaz@centrum.cz.
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