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Silver-coated monolithic columns for separation in radiopharmaceutical applications
O. Sedlacek, J. Kucka, F. Svec, M. Hruby,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
24478196
DOI
10.1002/jssc.201301325
Knihovny.cz E-zdroje
- MeSH
- 3-jodobenzylguanidin izolace a purifikace MeSH
- kovové nanočástice chemie MeSH
- methylmetakryláty chemie MeSH
- poréznost MeSH
- povrchové vlastnosti MeSH
- radiofarmaka izolace a purifikace MeSH
- stříbro chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
In this study, we demonstrate the preparation of a macroporous monolithic column containing anchored silver nanoparticles and its use for the elimination of excess radioiodine from the radiolabeled pharmaceutical. The poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith was first functionalized with cystamine and the free thiol groups liberated by reaction with borohydride. In-house-prepared silver nanoparticles were then attached by interaction with the surface thiols. The deiodization process was demonstrated with the commonly used radiopharmaceutical m-iodobenzylguanidine labeled with radionuclide iodine-125.
Citace poskytuje Crossref.org
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