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Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
I. Weinreb, S. Piscuoglio, LG. Martelotto, D. Waggott, CK. Ng, B. Perez-Ordonez, NJ. Harding, J. Alfaro, KC. Chu, A. Viale, N. Fusco, A. da Cruz Paula, C. Marchio, RA. Sakr, R. Lim, LD. Thompson, SI. Chiosea, RR. Seethala, A. Skalova, EB. Stelow,...
Nature genetics.
2014 ;
46 (11) :
1166-9.
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc15014063
Online
Full text
NLK
ProQuest Central
from 2000-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 1998-06-01 to 2015-11-30
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2000-01-01 to 1 year ago
PubMed
25240283
DOI
10.1038/ng.3096
Knihovny.cz E-resources
- MeSH
- Adenocarcinoma genetics pathology MeSH
- NIH 3T3 Cells MeSH
- Immunohistochemistry MeSH
- Immunoprecipitation MeSH
- Microscopy, Confocal MeSH
- Humans MeSH
- Mutation, Missense genetics MeSH
- Models, Molecular * MeSH
- Molecular Sequence Data MeSH
- Mutagenesis MeSH
- Mice MeSH
- Salivary Gland Neoplasms genetics pathology MeSH
- Protein Kinase C chemistry genetics MeSH
- Amino Acid Sequence MeSH
- Sequence Analysis, DNA MeSH
- Sequence Alignment MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
] Department of Pathology Memorial Sloan Kettering Cancer Center New York New York USA [2]
Cancer Genomics Platform Ontario Institute for Cancer Research Toronto Ontario Canada
Department of Medicine Memorial Sloan Kettering Cancer Center New York New York USA
Department of Pathology and Laboratory Medicine Charles University Prague Plzen Czech Republic
Department of Pathology Memorial Sloan Kettering Cancer Center New York New York USA
Department of Pathology University Health Network Toronto Ontario Canada
Department of Pathology University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA
Department of Pathology University of Virginia Medical Center Charlottesville Virginia USA
Department of Pathology Virginia Mason Hospital and Seattle Medical Center Seattle Washington USA
Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA
Informatics and Bio Computing Program Ontario Institute for Cancer Research Toronto Ontario Canada
References provided by Crossref.org
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