Detail
Článek
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Oxidative damage to nucleic acids and benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA adducts and chromosomal aberration in children with psoriasis repeatedly exposed to crude coal tar ointment and UV radiation

L. Borska, C. Andrys, J. Krejsek, V. Palicka, M. Chmelarova, K. Hamakova, J. Kremlacek, Z. Fiala,

. 2014 ; 2014 (-) : 302528.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15014081

The paper presents a prospective cohort study. Observed group was formed of children with plaque psoriasis (n=19) treated by Goeckerman therapy (GT). The study describes adverse (side) effects associated with application of GT (combined exposure of 3% crude coal tar ointment and UV radiation). After GT we found significantly increased markers of oxidative stress (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), significantly increased levels of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) DNA adducts (BPDE-DNA), and significantly increased levels of total number of chromosomal aberrations in peripheral lymphocytes. We found significant relationship between (1) time of UV exposure and total number of aberrated cells and (2) daily topical application of 3% crude coal tar ointment (% of body surface) and level of BPDE-DNA adducts. The findings indicated increased hazard of oxidative stress and genotoxic effects related to the treatment. However, it must be noted that the oxidized guanine species and BPDE-DNA adducts also reflect individual variations in metabolic enzyme activity (different extent of bioactivation of benzo[a]pyrene to BPDE) and overall efficiency of DNA/RNA repair system. The study confirmed good effectiveness of the GT (significantly decreased PASI score).

000      
00000naa a2200000 a 4500
001      
bmc15014081
003      
CZ-PrNML
005      
20150428115200.0
007      
ta
008      
150420s2014 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2014/302528 $2 doi
035    __
$a (PubMed)25197429
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Borska, Lenka $u Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
245    10
$a Oxidative damage to nucleic acids and benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA adducts and chromosomal aberration in children with psoriasis repeatedly exposed to crude coal tar ointment and UV radiation / $c L. Borska, C. Andrys, J. Krejsek, V. Palicka, M. Chmelarova, K. Hamakova, J. Kremlacek, Z. Fiala,
520    9_
$a The paper presents a prospective cohort study. Observed group was formed of children with plaque psoriasis (n=19) treated by Goeckerman therapy (GT). The study describes adverse (side) effects associated with application of GT (combined exposure of 3% crude coal tar ointment and UV radiation). After GT we found significantly increased markers of oxidative stress (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), significantly increased levels of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) DNA adducts (BPDE-DNA), and significantly increased levels of total number of chromosomal aberrations in peripheral lymphocytes. We found significant relationship between (1) time of UV exposure and total number of aberrated cells and (2) daily topical application of 3% crude coal tar ointment (% of body surface) and level of BPDE-DNA adducts. The findings indicated increased hazard of oxidative stress and genotoxic effects related to the treatment. However, it must be noted that the oxidized guanine species and BPDE-DNA adducts also reflect individual variations in metabolic enzyme activity (different extent of bioactivation of benzo[a]pyrene to BPDE) and overall efficiency of DNA/RNA repair system. The study confirmed good effectiveness of the GT (significantly decreased PASI score).
650    _2
$a 7,8-dihydro-7,8-dihydroxybenzo(a)pyren 9,10-oxid $x analýza $x chemie $7 D015123
650    _2
$a mladiství $7 D000293
650    _2
$a benzopyren $x chemie $x toxicita $7 D001564
650    _2
$a dítě $7 D002648
650    _2
$a předškolní dítě $7 D002675
650    12
$a chromozomální aberace $7 D002869
650    _2
$a dehet uhelný $x farmakologie $x terapeutické užití $7 D003033
650    _2
$a kohortové studie $7 D015331
650    _2
$a DNA $x chemie $7 D004247
650    _2
$a adukty DNA $x analýza $x chemie $7 D018736
650    _2
$a poškození DNA $x účinky léků $7 D004249
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a keratolytika $x farmakologie $x terapeutické užití $7 D007641
650    _2
$a lymfocyty $x cytologie $x metabolismus $7 D008214
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a masti $x farmakologie $x terapeutické užití $7 D009824
650    _2
$a oxidační stres $x účinky léků $7 D018384
650    _2
$a prospektivní studie $7 D011446
650    _2
$a psoriáza $x farmakoterapie $x metabolismus $x patologie $7 D011565
650    12
$a ultrafialové záření $7 D014466
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Andrýs, Ctirad $u Institute of Clinical Immunology and Allergology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, 50038 Hradec Kralove, Czech Republic. $7 mzk2008430528
700    1_
$a Krejsek, Jan $u Institute of Clinical Immunology and Allergology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, 50038 Hradec Kralove, Czech Republic.
700    1_
$a Palicka, Vladimir $u Institute of Clinical Biochemistry and Diagnosis, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
700    1_
$a Chmelarova, Marcela $u Institute of Clinical Biochemistry and Diagnosis, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
700    1_
$a Hamakova, Kvetoslava $u Clinic of Dermal and Venereal Diseases, University Hospital Hradec Kralove, Novy Hradec Kralove, 500 05 Hradec Kralove, Czech Republic.
700    1_
$a Kremlacek, Jan $u Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
700    1_
$a Fiala, Zdenek $u Institute of Hygiene and Preventive Medicine, Charles University in Prague, Faculty of Medicine in Hradec Kralove, 50038 Hradec Kralove, Czech Republic.
773    0_
$w MED00180520 $t Oxidative medicine and cellular longevity $x 1942-0994 $g Roč. 2014, č. - (2014), s. 302528
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25197429 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150420 $b ABA008
991    __
$a 20150428115504 $b ABA008
999    __
$a ok $b bmc $g 1071662 $s 896959
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 2014 $c - $d 302528 $i 1942-0994 $m Oxidative medicine and cellular longevity $n Oxid Med Cell Longev $x MED00180520
LZP    __
$a Pubmed-20150420

Najít záznam

Citační ukazatele

Možnosti archivace