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Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts
P. Denev, M. Kratchanova, M. Ciz, A. Lojek, O. Vasicek, D. Blazheva, P. Nedelcheva, L. Vojtek, P. Hyrsl,
Language English Country Poland
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24945135
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents isolation & purification pharmacology MeSH
- Antioxidants isolation & purification pharmacology MeSH
- Gram-Negative Bacteria drug effects growth & development MeSH
- Gram-Positive Bacteria drug effects growth & development MeSH
- Plants, Medicinal chemistry MeSH
- Humans MeSH
- Plant Leaves chemistry MeSH
- Macrophages cytology drug effects metabolism MeSH
- Microbial Sensitivity Tests MeSH
- Plant Components, Aerial chemistry MeSH
- Neutrophils cytology drug effects metabolism MeSH
- Opsonin Proteins pharmacology MeSH
- Lipid Peroxidation drug effects MeSH
- Polyphenols isolation & purification pharmacology MeSH
- Primary Cell Culture MeSH
- Reactive Oxygen Species antagonists & inhibitors metabolism MeSH
- Plant Extracts isolation & purification pharmacology MeSH
- Tetradecanoylphorbol Acetate pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The present study provides a comprehensive data on the antioxidant, antimicrobial and neutrophil-modulating activities of extracts from six medicinal plants--blackberry (Rubus fruticosus) leaves, chokeberry (Aronia melanocarpa) leaves, hawthorn (Crataegus monogyna) leaves, lady's mantle (Alchemilla glabra) aerial parts, meadowsweet (Filipendula ulmaria) aerial parts and raspberry (Rubus idaeus) leaves. In order to analyze the antioxidant activity of the herbs, several methods (ORAC, TRAP, HORAC and inhibition of lipid peroxidation) were used. Blackberry leaves and meadowsweet extracts revealed the highest antioxidant activities via all methods. All extracts studied blocked almost completely the opsonized zymosan particle-activated ROS production by neutrophils from human whole blood. On the other hand, the effect of extracts on phorbol myristate acetate-activated ROS production was much milder and even nonsignificant in the case of chokeberry leaves. This latter result suggests that extracts (apart from their antioxidative activity) interfere with the signaling cascade of phagocyte activation upstream of the protein kinase C activation. The antimicrobial activity of the investigated extracts against 11 human pathogens was investigated using three different methods. Meadowsweet and blackberry leaves extracts had the highest antimicrobial effect and the lowest minimal inhibiting concentrations (MICs) against the microorganisms tested.
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- $a Denev, Petko $u Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Laboratory of Biologicaly Active Substances, Plovdiv, Bulgaria.
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- $a Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts / $c P. Denev, M. Kratchanova, M. Ciz, A. Lojek, O. Vasicek, D. Blazheva, P. Nedelcheva, L. Vojtek, P. Hyrsl,
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- $a The present study provides a comprehensive data on the antioxidant, antimicrobial and neutrophil-modulating activities of extracts from six medicinal plants--blackberry (Rubus fruticosus) leaves, chokeberry (Aronia melanocarpa) leaves, hawthorn (Crataegus monogyna) leaves, lady's mantle (Alchemilla glabra) aerial parts, meadowsweet (Filipendula ulmaria) aerial parts and raspberry (Rubus idaeus) leaves. In order to analyze the antioxidant activity of the herbs, several methods (ORAC, TRAP, HORAC and inhibition of lipid peroxidation) were used. Blackberry leaves and meadowsweet extracts revealed the highest antioxidant activities via all methods. All extracts studied blocked almost completely the opsonized zymosan particle-activated ROS production by neutrophils from human whole blood. On the other hand, the effect of extracts on phorbol myristate acetate-activated ROS production was much milder and even nonsignificant in the case of chokeberry leaves. This latter result suggests that extracts (apart from their antioxidative activity) interfere with the signaling cascade of phagocyte activation upstream of the protein kinase C activation. The antimicrobial activity of the investigated extracts against 11 human pathogens was investigated using three different methods. Meadowsweet and blackberry leaves extracts had the highest antimicrobial effect and the lowest minimal inhibiting concentrations (MICs) against the microorganisms tested.
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- $a Kratchanova, Maria $u Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Laboratory of Biologicaly Active Substances, Plovdiv, Bulgaria.
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- $a Ciz, Milan $u Institute of Biophysics of the AS CR, Brno, Czech Republic.
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- $a Blazheva, Denitsa $u University of Food Technologies, Plovdiv, Bulgaria.
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- $a Vojtek, Libor $u Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic.
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- $a Hyrsl, Pavel $u Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic.
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