Integrin alpha6beta4 [integrin alfa6beta4]

topical
Terms

A9 Antigen
alpha(6)beta(4) Epithelial Integrin
alpha(6)beta(4) Integrin
alpha6 beta4 Integrin
Integrin alpha(6),beta(4)
Laminin-5 Receptor (alpha6beta4 Integrin)
TSP-180
Tumor Specific Protein-180 Complex

Persistent link   https://www.medvik.cz/link/D039161
Definition

This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.

DUI
D039161 MeSH Browser
CUI
M0154541
Previous indexing
Antigens, Surface (1988-2002); Integrins (1988-2002)
History note
2003; use INTEGRIN ALPHA6BETA4 (NM) 1988-2002
Public note
2003; INTEGRIN ALPHA6BETA4 was indexed under INTEGRINS; & ANTIGENS, SURFACE 1988-2002.

D Chemicals and Drugs
D12.776 Proteins 2 581
D12.776.543 Membrane Proteins 850
D12.776.543.750 Receptors, Cell Surface 511
D12.776.543.750.705 Receptors, Immunologic 129
D12.776.543.750.705.408 Integrins 118
D12.776.543.750.705.408.460 Receptors, Cytoadhesin 2
D12.776.543.750.705.408.460.170 Integrin alpha6beta4
D12.776.543.750.705.408.460.700 Platelet Glycoprotein GPIIb-IIIa Complex 93
D12.776.543.750.705.408.460.870 Receptors, Vitronectin 1
D12.776.543.750.705.876 Receptors, Laminin 1
D12.776.543.750.705.876.249 Integrin alpha1beta1
D12.776.543.750.705.876.280 Integrin alpha2beta1 3
D12.776.543.750.705.876.311 Integrin alpha3beta1 1
D12.776.543.750.705.876.374 Integrin alpha5beta1 3
D12.776.543.750.705.876.500 Integrin alpha6beta1
D12.776.543.750.705.876.750 Integrin alpha6beta4