Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.

DUI

D039222 MeSH Browser

CUI

M0230961

Previous indexing

Integrins (1994-2002)

History note

2003; use INTEGRIN ALPHA1BETA1 (NM) 1994-2002

Public note

2003; INTEGRIN ALPHA1BETA1 was indexed under INTEGRINS 1994-2002