Integrin alpha6beta1 [integrin alfa6beta1]
- Terms
-
alpha 6 beta 1 Integrin
alpha6beta1 Integrin
CD49f-CD29
Integrin alpha(6)beta(1)
Integrin alpha6Abeta1
Integrin alpha6Bbeta1
Platelet Glycoprotein I'c-IIa
VLA-6
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
- DUI
- D039121 MeSH Browser
- CUI
- M0208151
- Previous indexing
- Integrins (1992-2002)
- History note
- 2003; use INTEGRIN ALPHA6BETA1 (NM) 1992-2002
- Public note
- 2003; INTEGRIN ALPHA5BETA1 was indexed under INTEGRINS 1992-2002
Allowable subheadings
- AD
- administration & dosage
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PH
- physiology
- RE
- radiation effects
- TU
- therapeutic use
- UL
- ultrastructure