Transmembránové proteiny ze skupiny adhezních molekul zajišťující vazbu buňky na extracelulární matrix (vazba k fibronektinu, lamininu) nebo k povrchu jiných buněk (interakce s Ig superfamily). Jsou exprimovány na řadě typů buněk, vč. lymfocytů či mákrofágů. Patří k nim např. VLA, LFA-1, CD11CD18. Jsou tvořeny alfa a beta řetězci. Beta řetězce se dále dělí (beta1 odpovídá CD29, beta2 CD18, beta3 CD61). (cit. Velký lékařský slovník online, 2016 http://lekarske.slovniky.cz/ )

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.

Anotace

prefer specifics

DUI

D016023 MeSH Prohlížeč

CUI

M0024497

Předchozí užití

Glycoproteins (1966-1987); Membrane Glycoproteins (1988-1989); Receptors, Endogenous Substances (1973-1989); Receptors, Immunologic (1980-1989)

Historická pozn.

90

Veřejná pozn.

90